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The electrophysiological expression of calcium channels and of apamin sensitive calcium activated potassium channels is abolished in skeletal muscle cells from mice with muscular dysgenesis

, : The electrophysiological expression of calcium channels and of apamin sensitive calcium activated potassium channels is abolished in skeletal muscle cells from mice with muscular dysgenesis. Biochemical & Biophysical Research Communications 136(3): 935-940

Action potentials of myotubes in culture prepared from 18-19 day-old mouse embryos have a contractile activity and action potentials that are followed by a long lasting after hyperpolarisation (ahp) which is blocked by apamin. Myotubes prepared from embryos of mice with muscular dysgenesis (mdg/mdg) did not contract and had action potentials which were never followed by a.h.p.'s. Voltage-clamp experiments have shown (i) that Na+ channel activity was identical in mutant and control muscles and (ii) that the activity of fast and slow Ca2+ channels was nearly absent in the mutant.

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