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The electrophysiological expression of calcium channels and of apamin sensitive calcium activated potassium channels is abolished in skeletal muscle cells from mice with muscular dysgenesis






Biochemical & Biophysical Research Communications 136(3): 935-940

The electrophysiological expression of calcium channels and of apamin sensitive calcium activated potassium channels is abolished in skeletal muscle cells from mice with muscular dysgenesis

Action potentials of myotubes in culture prepared from 18-19 day-old mouse embryos have a contractile activity and action potentials that are followed by a long lasting after hyperpolarisation (ahp) which is blocked by apamin. Myotubes prepared from embryos of mice with muscular dysgenesis (mdg/mdg) did not contract and had action potentials which were never followed by a.h.p.'s. Voltage-clamp experiments have shown (i) that Na+ channel activity was identical in mutant and control muscles and (ii) that the activity of fast and slow Ca2+ channels was nearly absent in the mutant.

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Accession: 006670545



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