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The electrophysiological expression of calcium channels and of apamin sensitive calcium activated potassium channels is abolished in skeletal muscle cells from mice with muscular dysgenesis


, : The electrophysiological expression of calcium channels and of apamin sensitive calcium activated potassium channels is abolished in skeletal muscle cells from mice with muscular dysgenesis. Biochemical & Biophysical Research Communications 136(3): 935-940

Action potentials of myotubes in culture prepared from 18-19 day-old mouse embryos have a contractile activity and action potentials that are followed by a long lasting after hyperpolarisation (ahp) which is blocked by apamin. Myotubes prepared from embryos of mice with muscular dysgenesis (mdg/mdg) did not contract and had action potentials which were never followed by a.h.p.'s. Voltage-clamp experiments have shown (i) that Na+ channel activity was identical in mutant and control muscles and (ii) that the activity of fast and slow Ca2+ channels was nearly absent in the mutant.


Accession: 006670545

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Related references

Romey, G.; Rieger, F.; Renaud, J.F.; Pinçon-Raymond, M.; Lazdunski, M., 1986: The electrophysiological expression of Ca2+ channels and of apamin sensitive Ca2+ activated K+ channels is abolished in skeletal muscle cells from mice with muscular dysgenesis. Action potentials of myotubes in culture prepared from 18-19 day -old mouse embryos have a contractile activity and action potentials that are followed by a long lasting after hyperpolarization (ahp) which is blocked by apamin. Myotubes prepared f...

Romey, G.; Rieger, F.; Renaud, J.F.; Pincon Raymond, M.; Lazdunski, M., 1986: The electrophysiological expression of Ca2+ channels and of apamin sensitive Ca2+ activated K+ channels is abolished in skeletal muscle cells from mice with muscular dysgenesis. Action potentials of myotubes in culture prepared from 18-19 day -old mouse embryos have a contractile activity and action potentials that are followed by a long lasting after hyperpolarization (ahp) which is blocked by apamin. Myotubes prepared f...

Wikstrom, M.A.; E.M.nira, A., 1998: Calcium influx through N- and P/Q-type channels activated apamin-sensitive calcium-dependent potassium channels generating the late afterhyperpolarization in lamprey spinal neurons. Lamprey spinal neurons exhibit a fast afterhyperpolarization and a late afterhyperpolarization (AHP) which is due to the activation of apamin-sensitive SK Ca2+-dependent K+ channels (KCa) activated by calcium influx through voltage-dependent chann...

Schmid Antomarchi H.; Renaud J F.; Romey G.; Hugues M.; Schmid A.; Lazdunski M., 1985: The all or none role of innervation in expression of apamin receptor and of apamin sensitive calcium activated potassium channel in mammalian skeletal muscle. The long-lasting after-hyperpolarization(s) (AHP) tht follows the action potential in rat myotubes differentiated in culture is due to Ca2+-activated K+ channels. These channels have the property to be specifically blocked by the bee venom toxin a...

Hallworth, N.E.; Wilson, C.J.; Bevan, M.D., 2003: Apamin-sensitive small conductance calcium-activated potassium channels, through their selective coupling to voltage-gated calcium channels, are critical determinants of the precision, pace, and pattern of action potential generation in rat subthalamic nucleus neurons in vitro. Distinct activity patterns in subthalamic nucleus (STN) neurons are observed during normal voluntary movement and abnormal movement in Parkinson's disease (PD). To determine how such patterns of activity are regulated by small conductance pot...

Kawabata, A.; Kuroda, R.; Nagata, N.; Kawao, N.; Kawai, K.; Nishikawa, H.; Araki, H., 2001: Modulation by protease-activated receptors of gastrointestinal transit Roles of apamin-sensitive potassium channels and L-type calcium channels. Japanese Journal of Pharmacology 85(Supplement 1): 104P

Blatz A.L.; Magleby K.L., 1986: Single apamin blocked calcium activated potassium channels of small conductance in cultured rat skeletal muscle. Nature (London) 323(6090): 718-720

Wikström, M.A.; E.M.nira, A., 1998: Calcium influx through N- and P/Q-type channels activate apamin-sensitive calcium-dependent potassium channels generating the late afterhyperpolarization in lamprey spinal neurons. Lamprey spinal neurons exhibit a fast afterhyperpolarization and a late afterhyperpolarization (AHP) which is due to the activation of apamin-sensitive SK Ca2+-dependent K+ channels (KCa) activated by calcium influx through voltage-dependent chann...

Yuhas, W.A.; Fuchs, P.A., 1999: Apamin-sensitive, small-conductance, calcium-activated potassium channels mediate cholinergic inhibition of chick auditory hair cells. Acetylcholine released from efferent neurons in the cochlea causes inhibition of mechanosensory hair cells due to the activation of calcium-dependent potassium channels. Hair cells are known to have large-conductance, "BK"-type potassium...

Cognard C.; Romey G.; Galizzi J P.; Fosset M.; Lazdunski M., 1986: Dihydropyridine sensitive calcium channels in mammalian skeletal muscle cells in culture electrophysiological properties and interactions with calcium channel activator bay k 8644 and inhibitor pn 200 110. The whole-cell patch-clamp technique has been used to analyze the properties of the dihydropyridine-sensitive Ca2+ channel in rat skeletal muscle cells (myoballs) in culture. The potential dependence of Ca2+-channel activation is similar to that o...