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The electroretinogram c wave and slow p iii in albino rabbit with a special reference to changes in peak time and amplitude under various stimulus durations






Nippon Ganka Gakkai Zasshi 90(3): 466-471

The electroretinogram c wave and slow p iii in albino rabbit with a special reference to changes in peak time and amplitude under various stimulus durations

In order to clarify stimulus duration more suitable for recording the c-wave reflecting an activity of the retinal pigment epithelium, changes in peak time and amplitude of both the c-wave and the slow PIII under various stimulus durations were investigated. A nonpolarizable zinc zinc-sulphate electrode was placed on the cornea of a mydriatized and dark-adapted eye of an anesthetized adult albino rabbit. Stimulus intensity was fixed at 500 lx. The DC-registered c-wave was recorded under various stimulus durations ranging from 0.25 to 10 seconds. The slow PIII was isolated by intravenous injection of Na-iodate (30 mg/kg) and intravitreal injection of Na-aspartate (425 mM, 0.1 ml). The slow PIII was also recorded in the same way as the c-wave recording. The peak time of the slow PIII was shorter than that of the c-wave under the stimulus duration of less than 3.5 seconds, but peak time of the c-wave and the slow PIII were almost same under the stimulus duration of more than 3.5 seconds. The amplitude of the slow PIII (defined in the present experiment as a distance from a base line at the same point as the peak time of the c-wave) was compared with the amplitude of the c-wave. Under less than 1 second, the amplitude of the slow PIII was smaller than that of the c-wave, but became larger beyond the c-wave under more than 1 second. Under less than 4 seconds, the less the stimulus duration, the smaller the contribution ratio of the slow PIII to producing the c-wave amplitude. In order to minimize influence of the slow PIII on the c-wave, stimulus duration suitable for recording the c-wave seems to be less than 4 seconds.


Accession: 006670554



Related references

Yoshimura, Y.; Onoe, S.; Mori, T.; Takahashi, Y.; Tazawa, Y., 1986: The ERG c-wave and slow PIII in albino rabbit. With special reference to changes in peak time and amplitude under various stimulus durations. Nippon Ganka Gakkai Zasshi 90(3): 466-471

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