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The elimination and distribution of components of welding fumes from lung deposits in the guinea pig

Annals of Occupational Hygiene 22(1): 33-41

The elimination and distribution of components of welding fumes from lung deposits in the guinea pig

The fate of metallic element components of welding fume particles deposited in the lungs of guinea pigs was studied by radioactive labeling produced by prior neutron activation of the material. Neutron irradiated material, collected from fumes of metal inert gas welding, using stainless steel wire, was administered by intratracheal injection. The elimination pattern of elements from the lung deposits was established by a whole body and thoracic scanning technique in vivo and by analysis of radioactivity in feces and urine. Distribution of components in major organs and blood was determined by analysis of tissue samples post mortem. Major elimination was via the gastrointestinal tract and some systemic distribution of soluble components of Fe, Cr, Co and Ni occurred via the blood.

Accession: 006670627

PMID: 543579

DOI: 10.1093/annhyg/22.1.33

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