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The elimination of albumin poly vinyl pyrrolidone and dextran from the circulation in sheep

Journal of the South African Veterinary Association 46(3): 245-247

The elimination of albumin poly vinyl pyrrolidone and dextran from the circulation in sheep

The rates of elimination of iodinated human serum albumin (albumin-125I), polyvinylpyrrolidone (PVP-125I) and tritiated dextran (dextran-methoxy-3H) (MW of 69,000-72,000, 30,00-40,000 and 60,000-90,000, respectively) from the circulation of sheep were studied. Albumin and PVP initially disappeared from the circulation rapidly having half-life times (t1/2) of 10.5 .+-. 3.7 and 43 .+-. 45 h, respectively. This phase is regarded as being due to dequilibration within the initial volume of distribution, the rate being determined primarily by the relative molecular weight of the molecule. Hereafter PVP-125I was eliminated considerably faster (t1/2 = 176 .+-. 39 h) principally via the kidneys. The limited data available for dextran-3H suggests that this particular substance is rapidly excreted via the kidneys (t1/2 = 9 h). [These substances are used as plasma expanders.].

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Accession: 006670635

PMID: 1219105

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