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The embryotoxic and osteolathyrogenic effects of semicarbazide

, : The embryotoxic and osteolathyrogenic effects of semicarbazide. Toxicology 36(2-3): 183-198

The osteolathyrogenic agent semicarbazide was assayed for its toxicity and teratogenicity using early embryos of the frog Xenopus laevis. The 96-h LC50 is 1504.20 mg/1 while the 96-h EC50 is 76.28 mg/1. Embryo length is altered prior to the onset of other effects indicated by a reduction in stage of development. The major malformation is associated with the notochord where the notochordal sheath is reduced owing to the disruption in the maturation and/or deposition of the connective tissue fibers.

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Accession: 006670830

PMID: 4049430

DOI: 10.1016/0300-483x(85)90053-8

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