Section 7
Chapter 6,673

The escherichia coli gene encoding heat stable toxin is a bacterial transposon flanked by inverted repeats of insertion sequence 1

S.M.; Heffron, F.; Mccarthy, B.J.

Nature (London) 277(5696): 453-456


ISSN/ISBN: 0028-0836
Accession: 006672641

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Restriction endonuclease subclones of the Escherichia coli gene encoding the heat stable (ST) toxin exhibit a stem and loop structure similar to those seen in many procaryotic transposons. An EcoRI DNA fragment encoding tetracycline (Tc) resistance but no transposition functions was spliced into the ST gene in 1 of these subclones. By monitoring Tcr, the ST gene was shown to transpose. Restriction and DNA sequence data strongly suggest that the ST transposon, Tn1681, is flanked by inverted repeats of IS1.

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