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The excised leader of human cytochrome c oxidase subunit i messenger rna which contains the origin of mitochondrial dna light strand synthesis accumulates in mitochondria and its polyadenylated



The excised leader of human cytochrome c oxidase subunit i messenger rna which contains the origin of mitochondrial dna light strand synthesis accumulates in mitochondria and its polyadenylated



Molecular & Cellular Biology 7(2): 925-931



We identified a polyadenylated RNA species which contains the origin of human mitochondrial DNA light-strand synthesis of the surrounding complementary sequences of the four light-strand-encoded tRNAs. This RNA (RNA 9L) is probably derived form the leader portion of RNA 6 which is excised during the formation of the mature cytochrome c oxidase subunit mRNA (RNA 9). The high degree of secondary structure of this RNA is presumably responsible for its anomalous electrophoretic behavior in denaturing polyacrylamide gels.

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Accession: 006674342

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