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The experimental study of endoscopic hyperthermia with neodymium yag laser the 2nd report the thermal distribution on the canine gastric mucosa and histological studies of the canine stomach



The experimental study of endoscopic hyperthermia with neodymium yag laser the 2nd report the thermal distribution on the canine gastric mucosa and histological studies of the canine stomach



Gastroenterological Endoscopy 29(8): 1709-1714



Introduction: Since 1984, we have been studying the experimental studies of endoscopic local hyperthermia (laserthermia) with low power (less than 5 watts) Nd-YAG laser irradiation by using frosted probe (wide divergent ceramic contact probe). In this paper, the experimental data and the possibility of applying the endoscopic laserthermia were discussed. Materials and Methods: During the thermal control within the therapeutic level about 43.0.degree. C, the thermal distribution on serosal surface of the canine stomach was also measured with thermocamera under laparotomy (Figure 4). Histological studies: Correlations between the distance of thermal control and histological effects in the canine stomach were studied. One week after laserthermia, the stomach was removed and studied histologically by hematoxylin and eosin staining (H&E). Results: (1) Thermal distribution (Figure 7, 8); Tissue temperature was controlled to be nearly 43.0.degree. C within an area from 10 mm in diameter at about 6 mm of the control distance. (2) Histological findings in the canine stomach; One week after laserthermia, wider mucosal damages, submucosal fibrosis and intravascular thrombosis were recognized (Figure 10, 11, 12). Conclusions: It is enough and safe to the low power Nd-YAG laser under 3 watts for laserthermia. Effects of laserthermia were wider than those of the conventional laser irradiation, and may be considered as the results of thermal necrosis and intravascular thrombosis. Laserthermia can be applied to the endoscopic therapy of gastrointestinal neoplasms.

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