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The experimental study of endoscopic hyperthermia with neodymium yag laser the 3rd report the development of computer hyperthermia system and the thermal distribution on the canine gastric mucosa and histological studies of the canine stomach



The experimental study of endoscopic hyperthermia with neodymium yag laser the 3rd report the development of computer hyperthermia system and the thermal distribution on the canine gastric mucosa and histological studies of the canine stomach



Gastroenterological Endoscopy 29(11): 2443-2451



Introduction: Since 1979, endoscopic Nd-YAG laser therapy of the gastrointestinal neoplasms has been studied. There is no computer controlled Nd-YAG laser irradiation up to the present. Since 1984, we have been studying experimentally the endoscopic local hyperthermia (laserthermia) with low power (less than 5 watts) Nd-YAG laser irradiation. In this paper, we reported the experimental data and the possibility of applying the endoscopic laserthermia with the newly developed computer controlled system (Figure 3, 4, 5). Material and Methods: Under the thermal control within the therapeutic level about 43.0.+-.0.5.degree.C with the computer controlled laserthermia system, the thermal distribution on the mucosal surface in the canine stomach was measured with multithermocouples under laparotomy and gastrotomy (Figure 7, 8, 9, 10). Histological studies: Correlations between the distance of thermal control and histological effects in the canine stomach were studied. Soon after laserthermia, stomach was removed and studied histologically by hematoxylin and eosin staining (H and E). Results: (1) Thermal distribution (Figure 14); Tissue temperature was controlled nearly 43.0.degree.C within an area from 10 mm in diameter at about 6 mm of the control distance. At about 9 mm of the control distance, tissue temperature was over 65.degree.C. (2) Control of tissue temperature; It is possible to control tissue temperature stable for 20 min. with the computer controlled hyperthermia system. (3) Histological findings in the anine stomach; Soon after laserthermia, mucosal edema and congestion, and submucosal intravascular coagulation were observed (Figure 15). Conclusions: Safe and adequate laserthermia became possible by the development of computer hyperthermia system. Effects of laserthermia were wider than those of the conventional laser irradiation, and may be due to thermal necrosis and intravascular thrombosis. Laserthermia can be applied to the endoscopic therapy of gastrointestinal neoplasms.

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