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The fine structure of ito's fat storing cells in the liver of the mouse fetus after maternal treatment with vitamin a

The fine structure of ito's fat storing cells in the liver of the mouse fetus after maternal treatment with vitamin a

Senten Ijo 25(3): 165-174

The purpose of this study is to ascertain possible cytological effects of vitamin A administration to pregnant mice on the fat-storing cells (Ito cell) in the fetus liver. Though many external anomalies occurred in the fetus when vitamin A was given once on day 8 of gestation, it is conceivable that the appearance of teratogenicity may not be concerned in Ito cell because liver had not yet developed at this stage. When vitamin A was given once a day for four days consecutively from day 14 to day 17 of gestation little external anomalies appeared. By electron microscopy, cytological changes were found in Ito cell, especially the number of lipid droplets in the cytoplasm conspicuously increased. This proved that vitamin A administered to the mothers was carried into the fetuses through the placenta and Ito cells of the fetus liver had an ability to absorb vitamin A at the late stage of pregnancy.

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Accession: 006677499

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