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The fructose induced glycogenosis part 3 histochemical and morphometrical studies of glycogen metabolism in mouse liver after fructose overload


, : The fructose induced glycogenosis part 3 histochemical and morphometrical studies of glycogen metabolism in mouse liver after fructose overload. Beitraege zur Pathologie 161(1): 27-49

Feeding fructose for 7 days to a high glycogen content, combined with a high activity of glycogen-phosphorylase and glucose-6-phosphatase in mouse liver parenchyma. Glycogen-synthetase activity falls to a low level. The SER [smooth endoplasmic reticulum] and RER [rough endoplasmic reticulum] and the peroxisomes are reduced. The single volume of the hepatic nucleus is decreased and the hepatocellular chondrioma is transformed in a smaller number of larger mitochondria. Compared with the rat, the histochemically and morphologically analyzed organelles and enzymes of mouse liver show only slight quantitative differences. The increase of glucose-6-phosphatase and simultaneous reduction of endoplasmic reticulum membranes is illustrated by the dynamic structure of endoplasmic reticulum membranes, which adapt to metabolic changes. The variable turnover of different parts of endoplasmic reticulum membranes seems to be very important.

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Related references

Dietl, J.; Riede, U.N.; Kuhls, E.; Sasse, D., 1977: The fructose induces "glycogenosis". III. Histochemical and morphometrical studies of glycogen metabolism in mouse liver after fructose overload. After feeding fructose for 7 days rat liver cells show an accumulation of glycogen, a high activity of glucose-6-phosphatase combined with a SER- and RER-reduction. This result was reviewed by mouse liver cells using histochemical and morphometric...

Matthaei, C.; Sasse, D.; Riede, U.N., 1976: Fructose induced glycogenosis part 2 histochemical studies of glycogen metabolism in rat liver after fructose overload and similar diets. Rats were given 60% fructose solution in water as the only nutritional source. Controls are given a solution of 60% glucose in water, an isocaloric Altromin-R-standard diet and an Altromin-R-standard diet ad lib. Reversion of fructose induced meta...

Matthaei, C.; Sasse, D.; Riede, U.N., 1976: The fructose induced "glycogenosis". II. Histochemical studies of glycogen metabolism in rat liver after fructose overload and similar diets. Feeding of fructose for 7 days has been morphometrically shown to induce a SER-reduction and an accumulation of glycogen in rat liver cells. This hypothetical model "glycogenosis" is investigated with histochemical methods. Rats are give...

Riede U.N.; Uhl H.; Seufer G.; Robausch T.; Boehm N.; Sasse D., 1975: The fructose induced glycogenosis part 1 ultrastructural and morphometric analysis of rat hepatocytes 7 days after fructose overload. Beitraege zur Pathologie 154(1): 63-82

Riede, U.N.; Uhl, H.; Seufer, G.; Robausch, T.; Böhm, N.; Sasse, D., 1975: The fructose induced "glycogenosis". I. Ultrastructural and morphometric analysis of rat hepatocytes 7 days after fructose overload. Infusion of fructose has been shown to stimulate the SER and to reduce the RER in rat liver cells. After feeding fructose of 7 days a glycogenosis of unknown pathogenesis occurs, which was analysed morphometrically. 60% fructose in water, was give...

Augustin, P.; Riede, U.N.; Sasse, D., 1978: Fructose induced glycogenosis. IV. Morphometric analysis of organelle regeneration in rat liver cells during the recovery phase following an initial loading with fructose. After 7 days administration of a 60% solution of fructose in water as the only source of food and drink, a massive storage of glycogen is found in [rat] hepatocytes, accompanied by a hypoplasia of the organelles. Three days return to a normal diet...

Augustin, P.; Riede, U.N.; Sasse, D., 1978: Fructose induced glycogenosis 4. morphometric analysis of organelle regeneration in rat liver cells during the recovery phase following an initial loading with fructose. After 7 days administration of a 60% solution of fructose in water as the only source of food and drink, a massive storage of glycogen is found in [rat] hepatocytes, accompanied by a hypoplasia of the organelles. Three days return to a normal diet...

Rauschenbach, P.; Lamprecht, W., 1964: Incorporation of 14C-labelled glucose and fructose into liver glycogen. On fructose metabolism in the liver. Hoppe-Seyler's Zeitschrift für Physiologische Chemie 339(1): 277-292

Kaufmann, U.; Froesch, E.R., 1973: Inhibition of phosphorylase-a by fructose-1-phosphate, alpha-glycerophosphate and fructose-1,6-diphosphate: explanation for fructose-induced hypoglycaemia in hereditary fructose intolerance and fructose-1,6-diphosphatase deficiency. European Journal of Clinical Investigation 3(5): 407-413

Uzu, H., 1961: Experimental studies of fructose metabolism. 1. In vitro studies on the fructose metabolism of isolated liver slices and diaphragm of the rat. Naika Hokan. Japanese Archives of Internal Medicine 8: 1-9