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The fructose induced glycogenosis part 3 histochemical and morphometrical studies of glycogen metabolism in mouse liver after fructose overload

, : The fructose induced glycogenosis part 3 histochemical and morphometrical studies of glycogen metabolism in mouse liver after fructose overload. Beitraege zur Pathologie 161(1): 27-49

Feeding fructose for 7 days to a high glycogen content, combined with a high activity of glycogen-phosphorylase and glucose-6-phosphatase in mouse liver parenchyma. Glycogen-synthetase activity falls to a low level. The SER [smooth endoplasmic reticulum] and RER [rough endoplasmic reticulum] and the peroxisomes are reduced. The single volume of the hepatic nucleus is decreased and the hepatocellular chondrioma is transformed in a smaller number of larger mitochondria. Compared with the rat, the histochemically and morphologically analyzed organelles and enzymes of mouse liver show only slight quantitative differences. The increase of glucose-6-phosphatase and simultaneous reduction of endoplasmic reticulum membranes is illustrated by the dynamic structure of endoplasmic reticulum membranes, which adapt to metabolic changes. The variable turnover of different parts of endoplasmic reticulum membranes seems to be very important.

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