EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The function of collagen carbohydrates in initiation of platelet aggregation


Thrombosis Research 11(2): 155-162
The function of collagen carbohydrates in initiation of platelet aggregation
Periodate modification of collagen [rat tail tendon] can yield a carbohydrate and hydroxylysine-less tropocollagen whose melting temperature is slightly higher than that of unmodified collagen, whose fibril formation in 0.05 M Tris is decreased, and whose fibril formation in plasma is abolished. The periodate-treated tropocollagen can bind to platelets, since displacement by unmodified collagen can be demonstrated, but cannot initiate PRP [platelet rich plasma] aggregation. Fibrils formed from periodate-treated collagen in 0.05 M Tris can initiate aggregation upon addition to PRP. The carbohydrate residues of collagen do play a role in its fibril formation but not in its platelet aggregation.

Accession: 006680349

PMID: 198916

DOI: 10.1016/0049-3848(77)90034-2

Download PDF Full Text: The function of collagen carbohydrates in initiation of platelet aggregation



Related references

Collagen carbohydrates are not involved in collagen initiated platelet aggregation. Thrombosis & Haemostasis 38(1): 80, 1977

Collagen requirements for initiation of platelet aggregation. Supplementum ... Ad Thrombosis and Haemostasis 63: 255-267, 1978

Von Willebrand factor present in fibrillar collagen enhances platelet adhesion to collagen and collagen-induced platelet aggregation. Journal of Thrombosis and Haemostasis 2(4): 660-669, 2004

The Sensitivity of Whole Blood Aggregation, Platelet Rich Plasma Aggregation and Platelet Function Analyzer in Detecting Aspirin Effect on Platelet Function. Blood 100(11): Abstract No 3819, November 16, 2002

Okadaic acid and vanadate inhibit collagen-induced platelet aggregation; the functional relation of phosphatases on platelet aggregation. Thrombosis Research 67(4): 345-354, 1992

Okadaic acid and vanadate inhibit collagen-induced platelet aggregation: The functional relation of phosphatases on platelet aggregation. Thrombosis Research 67(4): 345-354, 1992

Function of the blood platelet. (I). Aggregation induced by collagen. Rinsho Byori. Japanese Journal of Clinical Pathology 22(10 Suppl): 99-99, 1974

Collagen induced platelet aggregation evidence of several mechanisms for the induction of platelet release by collagen. Thrombosis Research 10(5): 743-751, 1977

Collagen-mediated platelet aggregation: the role of multiple interactions between the platelet surface and collagen. Thrombosis and Haemostasis 43(2): 158-162, 1980

Platelet function in C6-deficient rabbits. Aggregation and secretion induced by collagen and zymosan. Immunology 29(1): 131-141, 1975