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The functional helper t cell repertoire specific for l glutamic acid 60 l alanine 30 l tyrosine 10

, : The functional helper t cell repertoire specific for l glutamic acid 60 l alanine 30 l tyrosine 10. Journal of Immunology 127(5): 1772-1777

The potential helper T cell repertoire specific for the random terpolymer GAT [L-glutamic acid60-L-alanine30-L-tyrosine10] of responder, nonresponder and (responder .times. nonresponder)F1 murine strains was studied. The ability of GAT-MBSA [methylated bovine serum albumin] immunized T cells to collaborate with DNP[dinitrophenyl]-specific primary and secondary B lymphocytes of each strain in response to the antigen DNP-GAT was tested with the splenic fragment culture system. There evidently are GAT-specific T lymphocytes in the responder, nonresponder and F1 strains, but these 3 GAT-specific T cell populations differ in their collaborative potential. New evidence was presented that the nonresponder status to the terpolymer GAT is due, in part, to a functional deletion of helper T cells capable of recognizing the antigen in the context of the nonresponder haplotype. A new responsive phenotype is evidenced when F1 secondary B cells are stimulated in nonresponder GAT-MBSA-primed recipients. In this case, rather than the IgG1 responses observed in such strain combinations to other antigens such as DNP-Hy [Limulus polyphemus hemocyanin] or DNP-GL.vphi.9 [L-glutamic acid55-L-lysine35-L-phenylalanine9], only IgM responses were obtained. This new phenotype may be the result of GAT-specific suppression of isotype switching by B cells bearing the nonresponder cell surface alloantigens.

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