EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The functional helper t cell repertoire specific for l glutamic acid 60 l alanine 30 l tyrosine 10


Journal of Immunology 127(5): 1772-1777
The functional helper t cell repertoire specific for l glutamic acid 60 l alanine 30 l tyrosine 10
The potential helper T cell repertoire specific for the random terpolymer GAT [L-glutamic acid60-L-alanine30-L-tyrosine10] of responder, nonresponder and (responder .times. nonresponder)F1 murine strains was studied. The ability of GAT-MBSA [methylated bovine serum albumin] immunized T cells to collaborate with DNP[dinitrophenyl]-specific primary and secondary B lymphocytes of each strain in response to the antigen DNP-GAT was tested with the splenic fragment culture system. There evidently are GAT-specific T lymphocytes in the responder, nonresponder and F1 strains, but these 3 GAT-specific T cell populations differ in their collaborative potential. New evidence was presented that the nonresponder status to the terpolymer GAT is due, in part, to a functional deletion of helper T cells capable of recognizing the antigen in the context of the nonresponder haplotype. A new responsive phenotype is evidenced when F1 secondary B cells are stimulated in nonresponder GAT-MBSA-primed recipients. In this case, rather than the IgG1 responses observed in such strain combinations to other antigens such as DNP-Hy [Limulus polyphemus hemocyanin] or DNP-GL.vphi.9 [L-glutamic acid55-L-lysine35-L-phenylalanine9], only IgM responses were obtained. This new phenotype may be the result of GAT-specific suppression of isotype switching by B cells bearing the nonresponder cell surface alloantigens.


Accession: 006680618



Related references

Dissection of the poly glutamic acid 60 alanine 30 tyrosine 10 specific t cell repertoire in h 21 k mice 1. poly glutamic acid 60 alanine 30 tyrosine 10 plus self i a k reactive t cell clones can recognize allo activating and or restriction determinants on nonself ia molecules. Immunogenetics 18(5): 475-488, 1983

Dissection of the poly glutamic acid 60 alanine 30 tyrosine 10 specific t cell repertoire in h 21k mice 2. use of mono clonal antibodies to study the recognition of ia antigens by poly glutamic acid 60 alanine 30 tyrosine 10 reactive t cell clones. Immunogenetics 18(6): 559-574, 1983

Major histo compatibility complex linked ir gene control of t cell responses l glutamic acid 60 l alanine 30 l tyrosine 10 t specific proliferating t cells and helper t cells are elicited in nonresponder mice immunized with soluble l glutamic acid 60 l alanine 30 l tyrosine 10. Journal of Immunology 130(4): 1521-1526, 1983

Serological analysis of antigen specific helper factors specific for a branched polymer containing tyrosine glutamic acid alanine and lysine and a linear polymer containing glutamic acid alanine and tyrosine. European Journal of Immunology 9(7): 501-506, 1979

Functional analysis of poly glutamic acid 60 alanine 30 tyrosine 10 specific t cell clones h 2 restricted mono clonal t helper cells do not regulate expression of antibody isotypes. Journal of Immunology 129(1): 217-221, 1982

Immune response to the p azo benzene arsonate poly l glutamic acid 60 alanine 30 tyrosine 10 conjugate role of i region genes in the selective activation of p azo benzene arsonate specific or poly l glutamic acid 60 alanine 30 tyrosine 10 specific t helper cells. Journal of Immunology 129(5): 2082-2088, 1982

Comparison of l glutamic acid 60 l alanine 30 l tyrosine 10 specific suppressor t cell factors from genetic responder and nonresponder mice to l glutamic acid 60 l alanine 30 l tyrosine. Federation Proceedings 41(4): ABSTRACT 4013, 1982

Immunoregulatory pathways in adult responder mice 3. establishment of a poly l glutamic acid 60 l alanine 30 l tyrosine 10 specific suppressor t cell clone from poly l glutamic acid 60 l alanine 30 l tyrosine 10 tolerant responders which afferently regulates delayed type hypersensitivity responses. JMCI (Journal of Molecular and Cellular Immunology) 2(1): 1-13, 1985

Functional helper activity of mono clonal t cell populations antigen specific and h 2 restricted cloned t cells provide help for in vitro antibody responses to tri nitro phenyl poly l tyrosine glutamic acid poly dl alanine poly l lysine. Proceedings of the National Academy of Sciences of the United States of America 78(10): 6431-6435, 1981

Cellular interactions of l glutamic acid 60 l alanine 30 l tyrosine 10 specific suppressor factors i. inhibition of the activity of gat specific helper t cell clones by monoclonal gat specific suppressor t cell factors. Journal of Immunology 136(3): 798-804, 1986