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The functional relationship between the polymerization and catalytic activity of beef liver glutamate dehydrogenase part 3 analysis of thusius critique



The functional relationship between the polymerization and catalytic activity of beef liver glutamate dehydrogenase part 3 analysis of thusius critique



Journal of Molecular Biology 129(1): 37-44



Thusius' critique (1977) of the authors' work on the functional relationship between the equilibrium polymerization and catalytic activity of beef liver glutamate dehydrogenase is refuted on a point by point basis. Thusius' critique is primarly based on data relating to the kinetics of the polymerization-depolymerization reaction. Such data are not in contradiction to the equilibrium thermodynamic analysis, for this analysis makes absolutely no predictions regarding the kinetics of the polymerization-depolymerization reaction. The important functional relationship between the polymerization and allosteric control of beef liver glutamate dehydrogenase has been clearly demonstrated on a purely experimental basis. The theoretical model is the only proposed model capable of quantitatively explaining the available data on the detailed equilibrium polymer distribution and associated level of catalytic activity as functions of effector and enzyme concentrations.

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