EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The functional state of sympathetic nerves in spontaneously diabetic mice


Diabetes 27(10): 969-974
The functional state of sympathetic nerves in spontaneously diabetic mice
I investigated biochemical parameters of sympathetic nerve function in spontaneously diabetic mice(C57 BL/KsJdb/db) and in their lean littermates. The concentration of norepinephrine (NE) in organs innervated by sympathetic nerves was significantly reduced in the heart, kidney, and salivary glands of mice (24 weeks old) with severe diabetic-like symptoms (blood glucose is greater than 300 mg./100ml.). In the spleen, vas deferens, and adrenal glands of the same animals the NE levels were not changed in relation to control. Other measurements of NE in young (six weeks old) diabetic mice revealed no differences between diabetic and nondiabetic controls. The turnover of NE, a measure of the functional state of sympathetic nerves, decreased significantly in the heart and salivary glands of 24-week-old mice but remained unchanged in the kidney and spleen. In young, diabetic mice the rates of NE turnover in several organs were similar to those found in age-matched controls. The hearts of 24-week-old diabetic mice contained significantly less dopamine-beta-hydroxylase (DBH), an intraneuronal enzyme active in the terminal step of NE biosynthesis. The kidney of the same animals was hypertrophic and showed a massive elevation of monoamine oxidase (MAO), an enzyme that degrades NE to inactive products. Other experiments showed that the regeneration of sympathetic neurons that follows the reversible chemical denervation with 6-hydroxydopamine was comparable in diabetic and nondiabetic animals. It appears that mice with spontaneous diabetes show changes of sympathetic nerve function similar to those noted in diabetic patients with autonomic neuropathy.


Accession: 006680810

PMID: 700260

DOI: 10.2337/diab.27.10.969



Related references

Axoplasmic transport of noradrenaline in the sciatic nerves of spontaneously diabetic mice. Diabetologia 16(3): 191-194, 1979

Glucose fructose sorbitol and inositol in sciatic nerves of spontaneously diabetic mice c 57bl ks dbdb. Biochemical Society Transactions 9(2): 289P, 1981

Effect of extracardiac nerves on the heart. 2. Effect of sympathetic nerves on the functional state of the heart. Biulleten' Eksperimental'noi Biologii i Meditsiny 37(4): 17-23, 1954

Ultrastructural and functional changes of the proximal tubular epithelial cells in the renal cortex from spontaneously diabetic KKAy mice. Journal of Electron Microscopy 48(4): 443-448, 1999

Long-term functional survival of microencapsulated allogeneic beta-cell lines in spontaneously diabetic NOD mice. Cell Transplantation 12(2): 158, 2003

Ultrastructural and functional changes of the proximal tubular epithelial cells in the renal cortex from spontaneously diabetic KKAy mice. Journal of Electron Microscopy 48(4): 443-448, 1999

Cell stations in the upper sympathetic chain Evidence that functional regeneration of sympathetic nerves in man occurs only in postganglionic neurones. Jour Neurosurg: 521-540, 1948

The role of chimerism on inducing tolerance to islet allografts in chemically induced diabetic mice and in spontaneously diabetic NOD mice. Cell Transplantation 12(2): 161-162, 2003

The effect of Leflunomide and cyclosporine on xenogeneic islet transplantation in STZ-induced diabetic mice and spontaneously diabetic mice. Cell Transplantation 5(5 SUPPL 2): 58, 1996

Differentiated changes in the activity of the sympathetic nerves induced by glycopenia in spontaneously hypertensive rats. Fiziologicheskii Zhurnal SSSR Imeni I. M. Sechenova 75(7): 899-903, 1989