+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The functional state of sympathetic nerves in spontaneously diabetic mice

, : The functional state of sympathetic nerves in spontaneously diabetic mice. Diabetes 27(10): 969-974

I investigated biochemical parameters of sympathetic nerve function in spontaneously diabetic mice(C57 BL/KsJdb/db) and in their lean littermates. The concentration of norepinephrine (NE) in organs innervated by sympathetic nerves was significantly reduced in the heart, kidney, and salivary glands of mice (24 weeks old) with severe diabetic-like symptoms (blood glucose is greater than 300 mg./100ml.). In the spleen, vas deferens, and adrenal glands of the same animals the NE levels were not changed in relation to control. Other measurements of NE in young (six weeks old) diabetic mice revealed no differences between diabetic and nondiabetic controls. The turnover of NE, a measure of the functional state of sympathetic nerves, decreased significantly in the heart and salivary glands of 24-week-old mice but remained unchanged in the kidney and spleen. In young, diabetic mice the rates of NE turnover in several organs were similar to those found in age-matched controls. The hearts of 24-week-old diabetic mice contained significantly less dopamine-beta-hydroxylase (DBH), an intraneuronal enzyme active in the terminal step of NE biosynthesis. The kidney of the same animals was hypertrophic and showed a massive elevation of monoamine oxidase (MAO), an enzyme that degrades NE to inactive products. Other experiments showed that the regeneration of sympathetic neurons that follows the reversible chemical denervation with 6-hydroxydopamine was comparable in diabetic and nondiabetic animals. It appears that mice with spontaneous diabetes show changes of sympathetic nerve function similar to those noted in diabetic patients with autonomic neuropathy.

(PDF same-day service: $19.90)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006680810

PMID: 700260

DOI: 10.2337/diab.27.10.969

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Tomoda A.; Yubisui T.; Tsuji A.; Yoneyama Y., 1979: Kinetic studies on met hemo globin reduction by human red cell nadh cytochrome b 5 reductase. The intermediate Hb which were produced by the partial reduction of methemoglobin [Met Hb] with human red cell NADH cytochrome b5 reductase were fractionated by preparative isoelectric focusing. These were composed of .alpha.3+.beta.2+ and .alpha....

Hunsley J.; Hanson R.K.; Parker K.C.H., 1988: A summary of the reliability and stability of mmpi scales. A sample of MMPI research published between 1970 and 1981 was analyzed to yield reliability and stability estimates for the MMPI scales. In fundamental agreement with previous research, moderately high levels of reliability and stability were foun...

Gurfinkel', V. S.; Kireeva, T. B.; Levik, Yu S., 1996: Effect of the vibration of postural muscles on balance maintenance in the frontal plane at different levels of stability. Vertical position maintenance was studied during the vibration of muscles responsible for femoral fascia tension. This vibration causes body deviation in the frontal plane. Unilateral and bilateral balanced vibration was used as was standing with...

Ferencz, Charlotte; Loffredo, Christopher A.; Correa Villasenor, Adolfo; Wilson, P. David, 1997: Perspectives in Pediatric Cardiology, Vol 5; Genetic and environmental risk factors of major cardiovascular malformations The Baltimore-Washington Infant Study, 1981-1989. This book is part of an on-going series presenting in-depth reviews of various topics in pediatric cardiology. This volume reviews risk factors, both genetic and environmental, of major cardiovascular malformations. Data for the analysis is taken...

Mccabe M.S., 1990: The oncology nurses role in technology transfer. Journal of Cancer Research & Clinical Oncology 116(SUPPL PART 1): 69

Van Doorn W.G.; De Witte Y.; Perik R.R.J., 1990: Effect of antimicrobial compounds on the number of bacteria in stems of cut rose flowers. The presence of chlorine in solution (bleach), a slow release chlorine (DICA), a quaternary ammonium compound (benzalkonium chloride), a hydroxyquinoline compound (HQC), or aluminium sulphate in the vase water decreased the number of bacteria in s...

Kao K.J.; Ramirez V.D., 1979: Induction of pituitary and mammary tumors in male fale and female rats by either 7 12 di methyl benz a anthracene estradiol implant or combined treatment. Implanting silastic capsules containing estradiol (E2) into castrated female and fale rats 5 days before 7,12-dimethyl benz(a)anthracene (DMBA) injection increased the incidence of mammary tumors from 0-44.4% and 30%, respectively. This E2 potenti...

Kafatos F.C.; Gelinas R., 1974: Messenger rna stability and the control of specific protein synthesis in highly differentiated cells. Paul, J (Ed ) Mtp (Medical And Technical Publishing Company) International Review Of Science, Biochemistry Series One, Vol 9 Biochemistry Of Cell Differentiation 380p Illus University Park Press: Baltimore, Md , U S A ; Butterworths: London, England Isbn 0-8391-1048-0; Isbn 0-408-70503-5 223-264

Brown, A.S.; Burrows, C.N.; Croft Caderao, K., 2014: Partial word knowledge in the absence of recall. Attributes of words can be known even when the words are not currently retrievable. Although repeatedly demonstrated for semantic and contextual dimensions, the evidence is ambiguous for structural characteristics. The present research demonstrate...

Janssen, K.; Matissek, R., 2002: Fatty acid tryptamides as shell indicators for cocoa products and as quality parameters for cocoa butter. The methods used to date to determine the shell content in cocoa products are very time-consuming, protracted and not specific enough, meaning that with the development of a new HPLC method using fluorescence detection, a considerably more specifi...