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The genetics of complement c 6 and complement c 7 in the dog polymorphism linkage locus duplication and silent alleles

The genetics of complement c 6 and complement c 7 in the dog polymorphism linkage locus duplication and silent alleles

Biochemical Genetics 21(1-2): 81-92

ISSN/ISBN: 0006-2928

The complement components C6 and C7 exhibit genetic polymorphism in the domestic dog. In the case of C6, there is a single locus with a null allele and 2 structural alleles; in the case of C7, there are 2 linked loci, each with 3 structural alleles. There is a null allele or locus deletion at one of these loci. In all cases, inheritance is autosomal and codominant. The C7 loci are closely linked to each other and to C6. This complex is not close to the dog major histocompatibility complex (MHC) locus.

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