Section 7
Chapter 6,689

The human gene for the beta subunit of nerve growth factor is located on the proximal short arm of chromosome 1

Francke, U.; de Martinville, B.; Coussens, L.; Ullrich, A.

Science 222(4629): 1248-1251


ISSN/ISBN: 0036-8075
PMID: 6648531
DOI: 10.1126/science.6648531
Accession: 006688220

Fragments of the recently cloned human gene for the .beta. subunit of nerve growth factor (.beta.-NGF) were used as hybridization probes in analyzing 2 sets of rodent-human somatic cell hybrids for the presence of human .beta.-NGF sequences. Results from the first set of hybrids assigned the human .beta.-NGF gene to chromosome 1 and ruled out the presence of sequencs of comparable homology on any other chromosomes. With the 2nd set of hybrids, which contained 7 different, but overlapping, regions of chromosome 1, the NGF locus was mapped to band 1p22.

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