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The human gene for the beta subunit of nerve growth factor is located on the proximal short arm of chromosome 1

Francke, U.; de Martinville, B.; Coussens, L.; Ullrich, A.

Science 222(4629): 1248-1251

1983

ISSN/ISBN: 0036-8075
PMID: 6648531
DOI: 10.1126/science.6648531
Accession: 006688220
Fragments of the recently cloned human gene for the .beta. subunit of nerve growth factor (.beta.-NGF) were used as hybridization probes in analyzing 2 sets of rodent-human somatic cell hybrids for the presence of human .beta.-NGF sequences. Results from the first set of hybrids assigned the human .beta.-NGF gene to chromosome 1 and ruled out the presence of sequencs of comparable homology on any other chromosomes. With the 2nd set of hybrids, which contained 7 different, but overlapping, regions of chromosome 1, the NGF locus was mapped to band 1p22.

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Related References

Francke, U.; De Martinville, B.; Coussens, L.; Ullrich, A. 1983: The human gene for the β subunit of nerve growth factor is located on the proximal short arm of chromosome 1 Science (Washington, D.C.) 222(4629): 1248-1251
Zabel, B.U.; Eddy, R.L.; Scott, J.; Shows, T.B. 1984: The human nerve growth factor gene ngf is located on the short arm of chromosome 1 Cytogenetics and Cell Genetics 37(1-4): 614
Russek, S.I.; Farb, D.H. 1994: The human GABA-A receptor beta-2 subunit gene is located on human chromosome 5Q34-Q35 Identification of an alpha-1-beta-2-gamma-2 gene cluster Society for Neuroscience Abstracts 20(1-2): 508
Darby, J.K.; Kidd, J.R.; Pakstis, A.J.; Sparkes, R.S.; Cann, H.M.; Ferrell, R.E.; Gerhard, D.G.; Riccardi, V.; Egeland, J.A.; Shooter, E.M. 1985: Linkage relationships of the gene for the beta subunit of nerve growth factor (NGFB) with other chromosome 1 marker loci Cytogenetics and Cell Genetics 39(2): 158-160
Darby, J.K.; Kidd, J.R.; Pakstis, A.J.; Sparkes, R.S.; Cann, H.M.; Ferrell, R.E.; Gerhard, D.G.; Riccardi, V.; Egeland, J.A.; Shooter, E.M.; Cavalli-Sforza, L.L.; Kidd, K.K. 1985: Linkage relationships of the gene for the β subunit of nerve growth factor ( Ngfb ) with other chromosome 1 marker loci Cytogenetic and Genome Research 39(2): 158-160
Cannizzaro, L.A.; Emanuel, B.S.; Cho, K.W.; Weinmann, R. 1986: The gene encoding the large subunit of human RNA polymerase II is located on the short arm of chromosome 17 American Journal of Human Genetics 38(6): 812-818
Deloukas, P.; Dauwerse, J.G.; Van Ommen, G.J.B.; Van Loon, A.P.G.M. 1994: The human NFKB3 gene encoding the p65 subunit of transcription factor NF-κB is located on chromosome 11q12 Genomics (San Diego, Calif.) 19(3): 592-594
Yang, F.ng T.L.; Kraus, J.P.; Francke, U. 1985: Gene for the beta subunit of propionyl coenzyme a carboxylase pccb is located on the long arm of human chromosome 3 3q13.3 q22 Cytogenetics and Cell Genetics 40(1-4): 783
Deloukas, P.; Dauwerse, J.G.; van Ommen, G.J.; van Loon, A.P. 1994: The human NFKB3 gene encoding the p65 subunit of transcription factor NF-kappa B is located on chromosome 11q12 Genomics 19(3): 592-594
Bottorff, D.; Stone, J.C. 1992: The murine leukemia inhibition factor gene (Lif) is located on proximal chromosome 11, not chromosome 13 Mammalian Genome: Official Journal of the International Mammalian Genome Society 3(12): 681-684
Floyd-Smith, G.; De Martinville, B.; Francke, U. 1986: An expressed beta-tubulin gene, TUBB, is located on the short arm of human chromosome 6 and two related sequences are dispersed on chromosomes 8 and 13 Experimental Cell Research 163(2): 539-548
Höppener, J.W.; de Pagter-Holthuizen, P.; Geurts van Kessel, A.H.; Jansen, M.; Kittur, S.D.; Antonarakis, S.E.; Lips, C.J.; Sussenbach, J.S. 1985: The human gene encoding insulin-like growth factor i is located on chromosome 12 Human Genetics 69(2): 157-160
Dracopoli, N.C.; Rose, A.E.; Whitfield, G.K.; Chance, P.; Bale, S.J.; Kourides, I.A.; Housman, D.E. 1987: Localization of two coordinately regulated genes the beta subunit of human tsh beta and nerve growth factor ngf beta using pulsed field gel electrophoresis American Journal of Human Genetics 41(3 Suppl): A164
Watkins, P.C.; Eddy, R.; Beck, A.K.; Vellucci, V.; Leverone, B.; Tanzi, R.E.; Gusella, J.F.; Shows, T.B. 1987: DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11 Dna 6(3): 205-212
Dracopoli, N.C.; Rettig, W.J.; Whitfield, G.K.; Darlington, G.J.; Spengler, B.A.; Biedler, J.L.; Old, L.J.; Kourides, I.A. 1986: Assignment of the gene for the beta subunit of thyroid-stimulating hormone to the short arm of human chromosome 1 Proceedings of the National Academy of Sciences of the United States of America 83(6): 1822-1826