+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The human interleukin 2 receptor beta chain (p70). Direct identification, partial purification, and patterns of expression on peripheral blood mononuclear cells



The human interleukin 2 receptor beta chain (p70). Direct identification, partial purification, and patterns of expression on peripheral blood mononuclear cells



Journal of Experimental Medicine 167(3): 1265-1270



IL-2 binds to high- and low-affinity receptors on activated T cells. The high-affinity receptor was hypothesized to consist of the noncovalent association between the .alpha. chain (IL-2-R-.alpha., p55) and a .beta. chain (IL-2-R-.beta., p70), whereas the low-affinity receptor consists of p55 without p70. We now directly identify p70 as a 65-77-kD glycoprotein doublet. Preparative quantities of the IL-2/p70 complex have been isolated. Further, we domonstrate that p70 is the principal IL-2- binding protein on both resting CD4+ and CD8+ T cells and that both p70 and p55 can be induced on normal B cells and moncytes.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 006688263

Download citation: RISBibTeXText

PMID: 2832509

DOI: 10.1084/jem.167.3.1265


Related references

Inhibition of interleukin-1 beta mRNA expression and interleukin-1 alpha and beta secretion by a specific human recombinant interleukin-1 receptor antagonist in human peripheral blood mononuclear cells. Immunology 77(2): 245-250, 1992

Regulation of interleukin-12 receptor beta1 chain expression and interleukin-12 binding by human peripheral blood mononuclear cells. European Journal of Immunology 27(1): 147-154, 1997

Fibrin matrices stimulate procoagulant activity, promote the expression of interleukin-1-beta, and suppress interleukin-1 receptor antagonist in human peripheral blood mononuclear cells. Clinical Research 41(2): 282A, 1993

12-Deoxyphorbol-13-O-phenylacetate 20 acetate [an agonist of protein kinase C beta 1 (PKC beta 1)] induces DNA synthesis, interleukin-2 (IL-2) production, IL-2 receptor alpha-chain (CD25) and beta-chain (CD122) expression, and translocation of PKC beta isozyme in human peripheral blood lymphocytes: evidence for a role of PKC beta 1 in human T cell activation. Journal of Clinical Immunology 14(4): 248-256, 1994

Gene expression of interleukin-12 receptor beta2 chain and Th1 population of peripheral blood mononuclear cells in chronic hepatitis C. Hepatology Research 22(4): 270-277, 2002

Fasting induces changes in peripheral blood mononuclear cell gene expression profiles related to increases in fatty acid beta-oxidation: functional role of peroxisome proliferator activated receptor alpha in human peripheral blood mononuclear cells. American Journal of Clinical Nutrition 86(5): 1515-1523, 2007

Interferon-beta not only inhibits interleukin-1beta and tumor necrosis factor-alpha but stimulates interleukin-1 receptor antagonist production in human peripheral blood mononuclear cells. European Cytokine Network 8(4): 345-349, 1997

Interleukin-1 beta, interleukin-1 receptor antagonist mRNA expression of peripheral blood mononuclear cells (PBMC) in idiopathic nephrotic syndrome (INS) detected by biotin-labelled probe in situ hybridization. Zhonghua Yi Xue Za Zhi 75(3): 152-4 190, 1995

Regulation of HLA-DR and invariant chain expression by human peripheral blood mononuclear cells with lead, interferon-gamma, or interleukin-4. Cellular Immunology 171(1): 1-9, 1996

An upregulation of interleukin-2 receptor, transferrin receptor expression and cytokine production mediated by hemin in human peripheral blood mononuclear cells. International Journal of Urology 3(3): 191-195, 1996

Molecular analysis of human interleukin-9 receptor transcripts in peripheral blood mononuclear cells. Identification of a splice variant encoding for a nonfunctional cell surface receptor. Journal of Biological Chemistry 273(37): 24016-24024, 1998

Complementarity-determining region 3 analysis of T cell receptor beta chain variable region in peripheral blood mononuclear cells cultured with interleukin-2. Nan Fang Yi Ke Da Xue Xue Bao 27(4): 433-435, 2007

Differential expression of the interleukin 2 receptor beta (p75) chain on human peripheral blood natural killer subsets. International Immunology 2(6): 481-486, 1990

Interleukin-4 downregulates the p70 chain of the IL-2 receptor on peripheral blood mononuclear cells. Cellular Immunology 136(1): 62-68, 1991

Interleukin 1 receptor antagonist il 1ra gene expression in lipopolysaccharide lps stimulated human peripheral blood mononuclear cells pbmc. Cytokine 3(5): 502, 1991