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The hypotensive effects of platelet activating factor 1 o alkyl 2 acetyl sn glyceryl 3 phosphoryl choline in rats guinea pigs rabbits and dogs


, : The hypotensive effects of platelet activating factor 1 o alkyl 2 acetyl sn glyceryl 3 phosphoryl choline in rats guinea pigs rabbits and dogs. Journal of Pharmacobio-Dynamics 6(11): 866-873

Platelet activating factor (PAF) showed profound and long-lasting hypotensive effects in normotensive and spontaneously hypertensive rats, guinea pigs, rabbits and dogs. Sensitivity to PAF was different among the animal species. The magnitude and duration of the hypotensive effect were dose-dependent. Apparently the hypotensive action was unlikely caused by actions on the central or autonomic nervous systems but seemed to be mainly due to some direct action(s) on the peripheral blood vessels.


Accession: 006689037

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Related references

Tanaka, S.; Kasuya, Y.; Masuda, Y.; Shigenobu, K., 1983: Studies on the hypotensive effects of platelet activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine) in rats, guinea pigs, rabbits, and dogs. Platelet activating factor (PAF) showed profound and long-lasting hypotensive effects in normotensive and spontaneously hypertensive rats, guinea pigs, rabbits and dogs. Sensitivity to PAF was different among the animal species. The magnitude and...

Liggitt H.D.; Huston L.; Leid R.W., 1983: Effects of platelet activating factor 1 0 alkyl 2 acetyl sn glyceryl 3 phosphoryl choline on bovine alveolar macrophage function. Journal de Pharmacologie (Paris) 14(SUPPL 1): 76

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Williams K.A.; Haslam R.J., 1984: Effects of sodium chloride and gtp on the inhibition of platelet adenylate cyclase by 1 o octadecyl 2 o acetyl sn glyceryl 3 phosphoryl choline synthetic platelet activating factor. The effects of NaCl and GTP on the inhibition of platelet adenylate cyclase by 1-O-octadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (1-octadecyl-2-acetyl-G-3-PC) were investigated using particulate fractions from human and rabbit platelets tha...

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