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The ideal human neoplasm



The ideal human neoplasm



Medical Hypotheses 5(10): 1133-1140



Clinical cancer manifestations are divided into the following 3 categories: primary cancer manifestations, e.g., cachexia; neoplasia, generally regarded as a local phenomenon; and secondary systemic sequelae of neoplasia, e.g., functional loss due to metastatic involvement. The theory coined as the Ideal Human Neoplasm (IHN) outlines the salient features of neoplastic progression and provides a framework in which this change may be expressed precisely and rigorously. Neoplasia is manifested by the follow 3 elementary biological phenomena: proliferation, differentiation and morphologenesis. Neoplasma are classified according to their replicative tissue group origin into 2 major groups: type I, which rise from rapidly replicating organs such as bone marrow, gastro-intestinal mucosa and endometrium; and type II neoplasma, originating in slowly proliferating organs, e.g., liver and kidney. The theory deals solely with adult type I neoplasms. It provides laws common to all type I neoplasms and outlines a common developmental pathway shared by all of them. Neoplasia is regarded as organ manifestation, a notion which disagrees with the commonly accepted one which regards neoplasia solely as a tissue manifestation. for is For instance, colon carcinoma viewed as an aberration of the whole mucosa and not only of its epithelial tissue. Carcinogenesis is marked by 2 processes proceeding together. A gradual and continuous expansion of progenitor cells is accompanied by their dedifferentiation. IHN forms a part of a more generalized theory which views neoplasia as a protective mechanism mobilized by the organism to withstand the gradual systemic deterioration of cancer, e.g., cachexia.

Accession: 006689232

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PMID: 522700

DOI: 10.1016/0306-9877(79)90031-8

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