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The identification of the active sites in human ceruloplasmin from the computer analysis of intermolecular and intramolecular homology






Molekulyarnaya Biologiya (Moscow) 21(4): 1124-1129

The identification of the active sites in human ceruloplasmin from the computer analysis of intermolecular and intramolecular homology

The identification of possible copper ligands in human ceruloplasmin was carried out by the computer similarity analysis for sequences of ceruloplasmin and several other copper oxidases: azurin, plastocyanin, superoxide dismutase, tyrosinase and hemocyanin. It follows from the analysis of inter- and intramolecular homology that copper active sites of different types appeared to be in close contacts within the ceruloplasmin molecule.

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Accession: 006689552



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