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The in vitro activity of netromycin in comparison with gentamicin tobramycin and amikacin



The in vitro activity of netromycin in comparison with gentamicin tobramycin and amikacin



Zhongguo Kanfshengsu Zazhi 12(6): 411-416



The in vitro activity of netromycin was tested and compared with that of gentamicin, tobramycin and amikacin against 548 strains of aerobic clinical isolates. Netromycin has good activity against Staphylococcus aureus and other Gram positive cocci except enterococci, being the most active one of the four aminoglycosides tested. The activity of netromycin against different bacteria of the family Enterobacteriaceae is similar to that of tobramycin but more active than gentamicin, it is the least active one against Pseudomonas aeruginosa in comparison with gentamicin, tobramycin and amikacin. About 25-86% of Gram positive cocci and 0-46% of Gram negative bacilli strains resistant to the other three aminoglycosides are still sensitive to netromycin. Further work is needed to elucidate the responsible mechanisms and to evaluate its potential usage in clinics.

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Accession: 006692220

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