The influence of dietary citrate on the absorption and retention of orally ingested lead

Spickett, J.T.; Bell, R.R.; Stawell, J.; Polan, S.

Agents and Actions 15(3-4): 459-462

1984


ISSN/ISBN: 0065-4299
PMID: 6524532
DOI: 10.1007/bf01972388
Accession: 006696399

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Abstract
The influence of dietary citrate on the toxicity of orally ingested lead was investigated in male weanling mice. Twenty-four animals were divided into 3 equal groups. Group 1 served as controls, groups 2 and 3 were given 20 .mu.g lead (as Pb acetate) per g/diet, group 3 also received 4% sodium citrate in the diet. After 5 wk, blood and tissue lead levels were measured. All mice given Pb-supplemented diets had higher concentrations of Pb in blood, liver, kidney, brain and bone than the control group, but the increase was significantly greater in the group given 4% sodium citrate in the diet. Apparently, dietary citrate at levels which can be present in food significantly increases Pb toxicity.

The influence of dietary citrate on the absorption and retention of orally ingested lead