The inhibition of migration inhibitory factor production by anti lymphocyte serum against sub populations of mouse and guinea pig lymphocytes

Goscicka, T.; Kieronska, D.; Rozalska, B.; Zablocki, B.

Bulletin de l'Academie Polonaise des Sciences Serie des Sciences Biologiques 24(1): 19-26


Accession: 006702830

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The influence of -lymphocyte antigens and H-2 antigens in impairing the surface receptor on T-lymphocytes was estimated by 3-fold absorption of the antisera with homologous thymocytes or fibroblasts. The ability of ALS to inhibit MIF production by mouse lymphocytes sensitized to alloantigen was more affected by absorption with fibroblasts than by absorption with thymocytes; the high (74.6%) inhibitory activity of antiserum against mouse lymph node cells was completely abolished by absorption with thymocytes and fibroblasts. The absorption with thymocytes in many cases resulted in the increased capacity of antiserum to suppress MIF production. This was observed in the action of antisera against guinea pig lymphocytes which were active in inhibiting MIF production only after absorption with thymocytes. The role of antibodies to alloantigens and T-lymphocyte antigen in impairing the surface receptor on T lymphocytes is discussed.