The interaction of link proteins with proteoglycan monomers in the absence of hyaluronic acid
Caterson, B.; Baker, J.
Biochemical and Biophysical Research Communications 80(3): 496-503
ISSN/ISBN: 0006-291X PMID: 637917 DOI: 10.1016/0006-291x(78)91596-6
Cartilage proteoglycan aggregates contain 3 classes of interacting components: proteoglycan monomers, hyaluronic acid and link proteins. Direct evidence is presented for a link protein to proteoglycan monomer association which hitherto has only been presumed to occur. When mixtures of purified link proteins and proteoglycan monomers were subjected to ultracentrifugation or gel chromatography under associative conditions, link proteins fractionated with proteoglycan.