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The longitudinal distribution of microphallus pygmaeus in the intestine of the mouse effect of diet and dose


, : The longitudinal distribution of microphallus pygmaeus in the intestine of the mouse effect of diet and dose. Tropical Biomedicine 3(2): 141-146

Male Swiss albino mice, aged 6 weeks, were orally inoculated with Microphallus pygmaeus using various dose sizes and volumes of inocula. The volume of the oral inoculum significantly changed the longitudinal distribution of the worms (P < 0.05) and increased the worm burden (P < 0.05). However, dose sizes have no apparent effect on the distribution of the worm in the intestine of the host. Most worms occurred in the ileum one day after oral inoculation to mice fed with normal diet but many remained in the duodenum in milk fed mice and in the anterior ileum when the mice were starved. The results suggest that the distribution of M. pygmaeus in the intestine of the mouse is affected by diet and volume of inoculum but not size of dose.

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