EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The loss of phenotypic traits by differentiated cells. VI. Behavior of the progeny of a single chondrocyte


, : The loss of phenotypic traits by differentiated cells. VI. Behavior of the progeny of a single chondrocyte. Journal of Experimental Medicine 130(2): 417-442

A single, functional, mitotically quiescent chondrocyte may be induced to reenter the mitotic cyde, and produce a progeny of over 10(11) cells. Sessile, adherent, polygonal cells deposit matrix, whereas amoeboid, dispersed, flattened fibroblastic cells do not. The prior synthetic history of a cell is of greater importance in determining whether the characteristic chondrogenic phenotype will be expressed, rather than growth in "permissive" or "nonpermissive" medium. Clonal conditions select for stem-like cells, some of whose progeny may become polygonal chondrocytes. The retention of the characteristic chondrogenic phenotype in vitro is favored by pruning the dedifferentiated chondrocytes which arise in these cultures. Dedifferentiated chondrocytes interfere with the deposition and synthesis of chondroitin sulfate by neighboring functional chondrocytes. Possible mechanisms are proposed to explain this type of cell-cell or cell exudate interference. If the progeny of a single, genetically programmed chondrocyte may or may not synthesize chondroitin sulfate, then extragenic sites in the cytoplasm or cell surface must influence the decision as to which cluster of "luxur" molecules the cell will synthesize.

(PDF same-day service: $19.90)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006712164

PMID: 5795101

DOI: 10.1084/jem.130.2.417

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Matsuo, M.; Ookita, K.; Takemine, H.; Koike, K.; Koike, M., 1985: Fatal case of pyruvate dehydrogenase deficiency. A Japanese neonate with fatal pyruvate dehydrogenase deficiency is described. The patient lapsed into a coma shortly after birth with severe metabolic acidosis caused by accumulation of lactate and pyruvate. Hyperammonemia was also present and fou...

Saharan, M. S.; Saharan, G. S.; Gupta, P. P., 2001: Pre-infectional anatomical characteristics in cluster bean leaf in relation to Alternaria blight resistance. Stomatal (frequency, size and index) and epidermal hairs (number and size) were compared in two moderately resistant (HG-75 and HG-365), four susceptible (HG-258, HFG-119, RGC-936 and RGC-1017) and one highly susceptible (FS277) genotypes of clust...

Frank, Otto, 1929: Theorie des Kardiographen. A short mathematical discussion of the statics, dynamics and efficiency of the transmission cardiograph, derived from the theory of the transmission sphygmograph published in the same number of the above Zeitschrift.

Gheerbrant Emmanuel; Sudre Jean; Iarochene Mohamed; Moumni Abdelkader, 2001: First ascertained African condylarth mammals (primitive ungulates; cf. Bulbulodentata and cf. Phenacodonta) from the earliest Ypresian of the Ouled Abdoun Basin, Morocco. We report here the discovery of the first well identified "condylarths" from Africa, from the phosphatic beds of Ouled Abdoun Basin, Morocco, of probable early Ypresian age, which have also yielded the oldest known proboscidean. Abdounod...

Furrer G.; Suter J., 1982: The upper Quaternary climate of Switzerland. Geographica Helvetica 37(2): 67

Garrard, Lisa; Ruis, Nancy; Tam, Connie; Andy, Robin; Luskey, Kenneth, 1993: Assessment of phage display as a method to generate GLP-1 analogs. Digestion 54(6): 393-394

Bellis, GA.; Gibson, DS.; Polkinghorne, IG.; Johnson, SJ.; Flanagan, M., 1993: Infection of Culicoides brevitarsis and C wadai (Diptera: Ceratopogonidae) with 4 Australian bluetongue virus serotypes. Arbovirus Research in Australia. 1992? ; 6: 197-199

Muller Siegwardt, B.; Blank, R.; Wolffram, S., 2006: Studies of the tryptophane-saving effect of SangrovitReg. in growing pigs. Sangrovit is based on a rhizome extract from Sanguinaria canadensis. Two 3-week-long studies with 12 boars were carried out to investigate its effects on feed intake after feeding on thryptophane-rich and -poor diets. Diets were based on no trypto...

Ushakova, N.A.; Preobrazhenskaya, M.E.; Bird, M.I.; Priest, R.; Semenov, A.V.; Mazurov, A.V.; Nifantiev, N.E.; Pochechueva, T.V.; Galanina, O.E.; Bovin, N.V., 2005: Monomeric and multimeric blockers of selectins: comparison of in vitro and in vivo activity. The potency of the oligosaccharides SiaLe(x), SiaLe(a), HSO(3)Le(x), and HSO(3)Le(a), their conjugates with polyacrylamide (PAA, 40 kD), and other monomeric and polymeric selectin inhibitors has been compared with that of the polysaccharide fucoid...

Hu, J. Y.; Ong, S. L.; Ng, W. J.; Liu, W., 2005: Use of a sequencing batch reactor for nitrogen and phosphorus removal from municipal wastewater. In this study, a suspended growth sequencing batch reactor (SBR) and an attached cum suspended growth SBR were used to investigate the performance characteristics of nitrogen and phosphorus (NP) removal from municipal sewage. The effects of three...