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The low incidence of multiple sclerosis in areas near the equator may be due to uv light induced suppressor cells to melanocyte antigens

, : The low incidence of multiple sclerosis in areas near the equator may be due to uv light induced suppressor cells to melanocyte antigens. Medical Hypotheses 19(4): 319-324

It has been shown by Elmets et al. that ultraviolet irradiation of the skin followed by the application of a normally sensitizing antigen results in tolerance induction to the antigen. This tolerance is due to the induction of suppressor T-cells specific for the antigen. Multiple sclerosis is more common in certain climates distant from the equator where there is less ultraviolet light (sunlight). I postulate that people near the equator are exposed to more sunlight and that the ultraviolet light from the sunlight aids in the induction of suppressor cells specific for melanocyte associated antigens. Since melanocytes are of neural crest origin and share antigenic determinants with neural tissues these suppressor cells may act to protect against multiple sclerosis which is probably an autoimmune disease directed against neural tissues.

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Lemlek J.; Heo J.; Cave V.; Beer S.; Nguyen T.; Iskandrian A.S., 1991: The merits of spect thallium imaging during adenosine coronary hyperemia in patients with remote q wave myocardial infarction. Journal of Nuclear Medicine 32(5 SUPPL): 979

Pastrana, M. T.; Lowit, C.; Pantoja, A. M.; Ferrer, F.; Boado, A., 1974: Carotene in the rumen with different feeds. Cattle with rumen fistulae were fed to appetite on forage only or with molasses and 1 or 2% urea. Carotene was estimated in coastcross Bermuda grass (Cynodon dactylon) before it was suspended in the rumen and 2 h later. From the original value of...

Figarella C.; Guy Crotte O.; Barthe C.; Amouric M., 1987: Human pancreatic proteins in normal and pathological states. Gastroenterologie Clinique et Biologique 11(12): 891-897

Mayor, P.; Lopez Bejar, M.; Rodriguez Gonzalez, E.; Paramio, M. T., 2001: Effects of the addition of glutathione during maturation on in vitro fertilisation of prepubertal goat oocytes. Glutathione ( gamma -glutamyl-cysteinyl-glycine; GSH) is an ubiquitous intracellular free thiol that improves development of the male pronucleus at fertilization and has also been implicated in promoting the development of preimplantation embryos....

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Wood W.B., 1981: Tooth size and morphology in a recent australian aboriginal population from broadbeach southeast queensland. Odontometric and morphologic observations were made of the dentition of skeletal remains of Australian aborgines from Broadbeach, Southeast Queensland. Tooth size, especially of the molars, was significantly larger than that reported for other rec...

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