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The low molecular weight autoinhibitor of sexual development in dictyostelium discoideum inhibits cell fusion and zygote differentiation






Canadian Journal of Biochemistry & Cell Biology 62(8): 722-731

The low molecular weight autoinhibitor of sexual development in dictyostelium discoideum inhibits cell fusion and zygote differentiation

During the sexual cycle of D. discoideum, zygote giant cell formation is regulated by an autoinhibitor. The autoinhibitor inhibits 2 events of zygote development: cell fusion and subsequent giant cell differentiation. The autoinhibitor is heat stable and has a MW around 500. Medium containing the autoinhibitor can be diluted 500-fold without loss of activity. Preliminary experiments show that, although levels of ammonia double during the 8-h period of autoinhibitor production, added ammonia does not mimic the inhibiting effect. cAMP at 1 mM inhibits both binucleate formation and differentiation, but the concentration of cAMP in 28-h cultures is only 13.4 pmol, a level which does not affect zygote development. Neither of these critical regulators of other developmental processes in D. discoideum is the autoinhibitor.

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Accession: 006712235



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