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The low molecular weight autoinhibitor of sexual development in dictyostelium discoideum inhibits cell fusion and zygote differentiation

, : The low molecular weight autoinhibitor of sexual development in dictyostelium discoideum inhibits cell fusion and zygote differentiation. Canadian Journal of Biochemistry & Cell Biology 62(8): 722-731

During the sexual cycle of D. discoideum, zygote giant cell formation is regulated by an autoinhibitor. The autoinhibitor inhibits 2 events of zygote development: cell fusion and subsequent giant cell differentiation. The autoinhibitor is heat stable and has a MW around 500. Medium containing the autoinhibitor can be diluted 500-fold without loss of activity. Preliminary experiments show that, although levels of ammonia double during the 8-h period of autoinhibitor production, added ammonia does not mimic the inhibiting effect. cAMP at 1 mM inhibits both binucleate formation and differentiation, but the concentration of cAMP in 28-h cultures is only 13.4 pmol, a level which does not affect zygote development. Neither of these critical regulators of other developmental processes in D. discoideum is the autoinhibitor.

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