EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The lung and oxygen toxicity


Archives of Internal Medicine 139(3): 347-350
The lung and oxygen toxicity
The toxic effects of prolonged exposure to O2 during [human] hyperoxic therapy are separable into an acute or edematous-exudative phase of O2 toxicity and a subacute or chronic proliferative phase. O2 toxicity is manifested by a characteristic pattern of inhibition of lung cell nucleotide and protein synthesis. The O2-free radicals and pulmonary antioxidant enzyme defense systems are discussed. An important feature lacking in the experimental studies of O2 toxicity is an explanation of individual variation in susceptibility/resistance to O2 toxicity.


Accession: 006712392

PMID: 371566

DOI: 10.1001/archinte.1979.03630400063023



Related references

On the pulmonary toxicity of oxygen part 1 the relationship of oxygen content to the effect of oxygen on the lung. Laboratory Investigation 21(5): 439-448, 1969

On the pulmonary toxicity of oxygen. I. The relationship of oxygen content to the effect of oxygen on the lung. Laboratory Investigation; A Journal of Technical Methods and Pathology 21(5): 439-448, 1969

Oxygen toxicity to the developing lung of the mouse: role of reactive oxygen species. Pediatric Research 40(2): 225-232, 1996

An experimental study on oxygen toxicity to respiratory tract and lung by exposure to hyperbaric oxygen. Chung-Ang Journal of Medicine 11(1): 49-58, 1986

Lung oxygen toxicity in rats is characterized by alteration in oxygen radical absorbance capacity and alleviated by blueberry supplementation. FASEB Journal 12(5): A815, March 20, 1998

Effect of oxygen toxicity and nitric acid-induced lung damage on drug absorption from the rat lung. Research Communications in Chemical Pathology and Pharmacology 15(1): 107-120, 1976

Differential oxygen- and 4HNE-induced cytotoxicity in cultured endothelial and epithelial cells An in vitro model for oxygen toxicity in the neonatal lung. Pediatric Research 39(4 PART 2): 75A, 1996

Pertussis toxin treatment decreases rat lung manganese superoxide dismutase activity Evidence for lung oxygen toxicity in air. FASEB Journal 8(4-5): A418, 1994

Pertussis toxin treatment alters manganese superoxide dismutase activity in lung. Evidence for lung oxygen toxicity in air-breathing rats. Journal of Clinical Investigation 93(6): 2482-2489, 1994

Cytochrome P-450 and oxygen toxicity. Oxygen-dependent induction of ethanol-inducible cytochrome P-450 (IIE1) in rat liver and lung. Biochemistry 28(10): 4499-4504, 1989