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The lung as a possible target organ for atrial natriuretic polypeptide secreted from the heart


Biochemical & Biophysical Research Communications 135(2): 515-520
The lung as a possible target organ for atrial natriuretic polypeptide secreted from the heart
Using a specific radioimmunoassay (RIA) for .alpha.-rat artrial natriuretic polypeptide (.alpha.-rANP), we have demonstrated the presence of a considerable amount (6.10 .+-. 0.38 ng/g) (mean .+-. SE) of .alpha.-rANP-like immunoreactivity (.alpha.-rANP-LI) in the rat lung, the first organ through which atrial natriuretic polypeptide (ANP) released from the heart passes. High performance gel permeation chromatography coupled with the RIA revealed that most of .alpha.-rANP-LI eluted at the position of a low molecular weight form corresponding to synthetic .alpha.-rANP. In 2- or 5-day water-deprived rats, the concentration and content of .alpha.-rANP-LI in the lung decreased significantly compared with those of control rats. In addition, water-deprivation induced a significant decrease in the plasma concentration of .alpha.-rANP-LI simultaneously determined. There was a significant positive correlation between the concentrations of .alpha.-rANP-LI in the lung and plasma (r=0.591, P < 0.01). These results indicate the presence of ANP in the lung and suggest physiological roles of ANP in pulmonary function.

Accession: 006712394

PMID: 2938578

DOI: 10.1016/0006-291x(86)90024-0

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