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The lung at high altitude: bronchoalveolar lavage in acute mountain sickness and pulmonary edema


, : The lung at high altitude: bronchoalveolar lavage in acute mountain sickness and pulmonary edema. Journal of Applied Physiology 64(6): 2605-2613

High-altitude pulmonary edema (HAPE), a severe form of altitude illness that can occur in young healthy individuals, is a noncardiogenic form of edema that is associated with high concentrations of proteins and cells in bronchoalveolar lavage (BAL) fluid (Schoene et al., J. Am. Med. Assoc. 256: 63-69, 1986). We hypothesized that acute mountain sickness (AMS) in which gas exchange is impaired to a milder degree is a precursor to HAPE. We therefore performed BAL with 0.89% NaCl by fiberoptic bronchoscopy in eight subjects at 4,400 m (barometric pressure = 440 Torr) on Mt. McKinley to evaluate the cellular and biochemical responses of the lung at high altitude. The subjects included one healthy control (arterial O2 saturation = 83%), three climbers with HAPE (mean arterial O2 saturation = 55.0 .+-. 5.0%), and four with AMS (arterial O2 saturation = 70.0 .+-. 2.4%). Cell counts and differentials were done immediately on the BAL fluid and the remainder was frozen for protein and biochemical analysis to be performed later. The results of this and of the earlier study mentioned above showed that the total leukocyte count (.times. 105/ml) in BAL fluid was 3.5 .+-. 2.0 for HAPE, 0.9 .+-. 0.4 for AMS, and 0.7 .+-. 0.6 for controls, with predominantly alveolar macrophages in HAPE. The total protein concentration (mg/dl) was 616.0 .+-. 3.3 for HAPE, 10.4 .+-. 8.3 for AMS, and 12.0 .+-. 3.4 for controls, with both large- (immunoglobulin M) and small- (albumin) molecular-weight proteins present in HAPE. There was evidence of complement activation (C5a) and release of thromboxane B2 and leukotriene B4 in HAPE but not in controls or AMS. Despite gas exchange impairment in AMS, the BAL fluid showed no evidence of abnormal protein or cell concentrations.

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Accession: 006712396

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Laurent, RF., 1992: On some overlooked species of the genus Liolaemus Wiegmann (Reptilia Tropiduridae) from Peru. Breviora. 31 January; 494: 1-33

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Sen S.; Sen A., 1975: Metallogeny and geochemistry of copper in sedimentary formation of the Indravati Group, Bastar District, Madhya Pradesh. Indian Minerals 29(1): 27-32

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White, T.R.; Thompson, R.C.; Penhale, W.J.; Pass, D.A.; Mills, J.N., 1982: Pathophysiology of Mesocestoides corti infection in the mouse. Liver histology and serum enzyme and protein changes were studies in two strains of mice showing different initial susceptibilities to infection with Mesocestoides corti. The results show an increase in ALT and AST levels during the period of inva...

Hestbjerg, H.; Elmholt, S.; Nielsen, K. F.; Felding, G., 2000: The ecology of toxin producing fungi. An understanding of the ecology of mycotoxin producing fungi is essential to prevent contamination of foods and feeds. The fungal genus Fusarium contains several important mycotoxin producing species including F. culmorum. The results from a study...

Srivastava, Alok K.; Rao, P. Haridas, 1994: Changes in the functional characteristics of wheat during high temperature storage. Storage of wheat at different temperatures showed considerable deterioration in grain quality. The deterioration was more in wheat stored for 5 months at 50 degree C. Storage of wheat at higher temperature for longer duration decreased both the 10...

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Anonymous, 1974: Special issue on genetic control of mosquitoes. This special issue is to highlight research carried out by the Unit on Genetic Control of Mosquitoes sponsored by the World Health Organization and the Indian Council of Medical Research over the last 4 years. The following are the papers that dea...

Carrillo G. A., 1979: Dynamic behaviour of fluvio-alluvial soils of Lima. Memorias del Congreso Panamericano de Mecanica de Suelos e Ingenieria de Fundaciones = Proceedings of the Panamerican Conference on Soil Mechanics and Foundation Engineering 6, Vol