EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The lung lysosomal hydrolases and phospholipase A in acute experimental pancreatitis with reference to heparin treatment


, : The lung lysosomal hydrolases and phospholipase A in acute experimental pancreatitis with reference to heparin treatment. Pathology, Research and Practice 181(5): 576-585

The pulmonary complications are severe sequelae of acute pancreatitis. The pathogenesis of these complications is unsolved. The purpose of this work was to evaluate the status of lung lysosomes and phospholipase A activity in acute experimental pancreatitis (AEP) and the effect of heparin as a potentially protective agent. Taurocholate-induced AEP in rats lasting 24 and 48 hours was treated with heparin intraperitoneally (2 mg/kg every 8 hours). The total activity of cathepsins and .BETA.-glucuronidase in lysosomal enriched subfraction increased markedly during 48 hours of AEP in untreated animals, but the relative free activity was maximal after 24 hours. Free activity of cathepsins and acid phosphatase in supernatant was maximal after 24 hours. The phospholipase A activity was maximally elevated (more than twofold) after 48 hours. Heparin prevented the increase of activity of .BETA.-glucuronidase, depressed the relative free activity of all investigated lysosomal hydrolases and inhibited the phospholipase A activity in the lung homogenate. Our results indicate the significance of labilisation of lung lysosomes and increment of phospholipase A activity in the lungs in the damage of this organ during AEP in the rats, and suggest the beneficial effect of heparin on these factors.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006712409

PMID: 2431400

DOI: 10.1016/S0344-0338(86)80152-2

Download PDF Full Text: The lung lysosomal hydrolases and phospholipase A in acute experimental pancreatitis with reference to heparin treatment


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

ROSENBERG.H.N.; MICHELSON.A.L., 1955: The use of pentaerythritol tetranitrate in chronic coronary insufficiency. American Journal of the Medical Sciences 230(3): 254-258

Navakauskiene, R.; Gineitis, A.; Magnusson, K.E., 1997: Cytoplasm-nuclear translocation of tyrosine-phosphorylated proteins during HL-60 cell differentiation. Molecular Biology of the Cell 8(SUPPL ): 216A, Nov

Zouboulis, C., C.; Buettner, P.; Djawari, D.; Kirch, W.; Keitel, W.; Garbe, C.; Von-Keyserlingk-Eberius, H.-Joachim; Orfanos, C., E., 1993: HLA pattern of Adamantiades-Behcet disease in Germany: Association with onset, clinical features and course in 39 patients. The frequencies of HLA-class antigens were studied in 39 patients with Adamantiades-Behcet's disease and were compared with those in 1915 healthy controls; both patients and controls were of German origin. Moreover, the correlations of HLA an...

Craddock, C.; Vrijenhoek, R.J.; Lively, C.M., 1993: Fish hybrids and the red queen. Trends in Ecology & Evolution 8(12): 458-458

Anonymous, 1982: Otitis media and fever. JAMA 247(7): 978-979

Maloney, D.M., 2002: Research subjects to be told about conflicts of interest. Human Research Report 17(2): 3-3

Brand, D., 1992: The use of lithium-chloride as a predation aversion agent for problem eagles in the Cape Province and Orange Free State, South Africa. Gabar: 72: 51-55

Szekeres, G.; Audouin, J.; Diebold, J., 1988: Reactive cells in non-Hodgkin's malignant lymphoma. Morphologiai Es Igazsagugyi Orvosi Szemle 28(2): 123-129

Kuikka J.T.; Rautio P.; Huttunen H.; Helin M.; Vainio P.; Tuppurainen T.; Huttunen K.; Lansimies E., 1987: Double tracer spect imaging with indium 111 anti myosin and technetium 99m rbc in myocardial lesions. Nuklearmedizin 26(4): 105-106

Mukherjee, G.; Rasmusson, B.; Linner, J.G.; Quinn, M.T.; Parkos, C.A.; Magnusson, K.E.; Jesaitis, A.J., 1998: Organization and mobility of CD11b/CD18 and targeting of superoxide on the surface of degranulated human neutrophils. A monoclonal IgM, specifically recognizing both CD11b and CD18 of human neutrophils, was used to examine the organization and mobility of CD11b/CD18 in the plasma membrane of human neutrophils degranulated by dihydrocytochalasin B (dhCB) treatment...