EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The lungs and causes of death in the nocturnal oxygen therapy trial


Chest 86(2): 230-233
The lungs and causes of death in the nocturnal oxygen therapy trial
Autopsy findings and a morphometric study of the lungs were compared in 18 subjects receiving nocturnal oxygen and 15 receiving continuous oxygen in the National Heart, Lung, and Blood Institute Nocturnal Oxygen Therapy Trial (about half of those who died). The emphysema score, average interalveolar wall distance, central airway lesions, peripheral airway lesions, and the ratio of weights of left ventricle plus septum to right ventricle were similar in the two groups. The causes of death in the two groups were also similar. This evidence supports the hypothesis that the improved prognosis observed with continuous oxygen therapy nocturnal oxygen therapy in patients with severe chronic airflow obstruction and hypoxemia was due to treatment. There was a trend for there to be more interstitial fibrosis and type 2 alveolar epithelial cell hyperplasia in those treated with nocturnal oxygen; in the hands of one observer, the type 2 cell hyperplasia was significant.


Accession: 006712422

PMID: 6378540

DOI: 10.1378/chest.86.2.230



Related references

Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Nocturnal Oxygen Therapy Trial Group. Annals of Internal Medicine 93(3): 391-398, 1980

Ambulatory oxygen therapy, exercise, and survival with advanced chronic obstructive pulmonary disease (the Nocturnal Oxygen Therapy Trial revisited). Respiratory Care 45(2): 204-11; Discussion 211-3, 2000

Is 12-hour oxygen as effective as 24-hour oxygen in advanced chronic obstructive pulmonary disease with hypoxemia? (The nocturnal oxygen therapy trial--NOTT). Chest 78(3): 419-420, 1980

Recruitment experience in the Nocturnal Oxygen Therapy Trial. Controlled Clinical Trials 8(4 Suppl): 121s-130s, 1987

A case report of data monitoring experience: the nocturnal oxygen therapy trial. Controlled Clinical Trials 3(2): 113-124, 1982

A randomized trial of nocturnal oxygen therapy in chronic obstructive pulmonary disease patients. European Respiratory Journal 14(5): 1002-1008, 1999

Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease a clinical trial. Annals of Internal Medicine 93(3): 391-398, 1980

Cheyne-Stoke respiration associated with chronic heart failure: nocturnal oxygen therapy, home oxygen therapy. Nihon Rinsho. Japanese Journal of Clinical Medicine 65 Suppl 5: 402-405, 2007

Results of a randomized multicenter study on nocturnal oxygen therapy in chronic obstructive lung disease not justifying conventional oxygen therapy. Revue des Maladies Respiratoires 16 Suppl 3: S31-S32, 1999

Respiratory pathology of sleep Results of a randomized multicenter study on nocturnal oxygen therapy in COPD do not justify conventional oxygen therapy. Revue des Maladies Respiratoires 16(SUPPL 3): 3S31-3S32, Jan, 1999