+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The lungs as a generator of prostacyclin

, : The lungs as a generator of prostacyclin. Annales de l'Anesthesiologie Francaise 21(6): 613-620

Under physiological conditions prostacyclin (PGI2) is the main metabolite of arachidonic acid that is generated and released by [cat] lungs. Apparently the generation of PGI2 by lungs is a continuous process and PGI2 is a circulating hormone, the concentration of which is 100-200 pg/ml higher in arterial blood than in mixed venous blood. The generation of PGI2 by lungs can be augmented by angiotensin II, bradykinin and arachidonic acid, provided that low concentrations of the substances are infused into pulmonary artery. Air pulmonary emboli and mechanical hyperventilation stimulate the lungs to generate more PGI2. Respiratory stimulants, such as lobeline or almitrine, are even more effective in this respect. This para-endocrine function of the lung may constitute an important physiological mechanism that protects coronary and cerebral arteries against thrombosis and atherosclerosis. the efficacy of this mechanism can be increased by pharmacological procedures. A link between ventilatory and nonventilatory function of the lungs is proposed. Hyperventilation increases the hormonal function of the lungs, i.e., stimulates PGI2 generation. A link between these functions of the lungs and homeostasis in cardiovascular system is proposed.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006712423

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Giesberts M.A.H.; Kroes A.A., 1972: Urinary glycosamino glycans in hunter hurler syndromes. Scandinavian Journal of Clinical & Laboratory Investigation Supplement 29(123): 13

Nansen P., 1984: Trypanosoma brucei induced blockage of expulsion of echinostoma revolutum and homologous echinostoma revolutum resistance in mice. Experiments were designed to study the effect of T. brucei on the expulsion of E. revolutum and on the development and maintenance of homologous E. revolutum resistance in the mouse. T. brucei given 3, 2 and 1 wk before and 1 wk after infection wi...

Neill D.B.; Sabol K.E., 1986: Cortical striatal relationships sensorimotor and visual functions in the rat. Society for Neuroscience Abstracts 12(2): 1224

Luckey, John A.; Smith, Lloyd M., 1993: Optimization of electric field strength for DNA sequencing in capillary gel electrophoresis. Analytical Chemistry 65(20): 2841-2850

Kim, Yh; Lee, Cs1; Yu, Ys1; Hong, Sbo, 1981: Fluctuation of wine quality an. Nongsa sihom yon'gu pogo Nongki nongka nongkyong = The Research reports of the Office of Rural Development 23(23): 88-94

Acharya, G., 2000: Approaches to valuing the hidden hydrological services of wetland ecosystems. This paper investigates the role of the production function approach in capturing the value of hydrological services of wetland ecosystems. Hydrological research in the Hadejia-Nguru wetlands in northern Nigeria suggests that the major role of the...

Barragry T.P.; Blatchford J.W.; Tuna I.C.; Lillehei T.J.; Ring W.S., 1987: Left ventricular dysfunction in a canine model of chronic cyanosis. Surgery (St Louis) 102(2): 362-370

Stark, C. N., 1930: The source of ropy milk bacteria in nature. The author reports studies of 7 types of bacteria causing ropiness, isolated from raw and pasteurized milk and from places in and around dairy barns. Of about 500 isolations studied, at least 75% were gram-negative rods producing acid and gas in l...

Normark S., 1987: Inactivation of the amp d gene causes semiconstitutive overproduction of the inducible citrobacter freundii beta lactamase. In Citrobacter freundii and Enterobacter cloacae, synthesis of AmpC .beta.-lactamase is inducible by the addition of .beta.-lactams to the growth medium. Spontaneous mutants that constitutively overproduce the enzyme occur at a high frequency. Whe...

Anonymous, 2011: Indicated Preterm Birth for Fetal Anomalies. Between 2% and 3% of pregnancies are complicated by fetal anomalies. For most anomalies, there is no advantage to late preterm or early-term delivery. The risks of maternal or fetal complication are specific for each anomaly. Very few anomalies po...