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The lungs in diabetes mellitus 2. phospho lipid analyses on the surfactant from broncho alveolar lavage fluid of alloxan induced diabetic rats


, : The lungs in diabetes mellitus 2. phospho lipid analyses on the surfactant from broncho alveolar lavage fluid of alloxan induced diabetic rats. Biochemical and Biophysical Research Communications 98(1): 163-168

The phospholipid content and composition in the surfactant from broncho-alveolar lavage fluid or alloxan-induced diabetic rats were analyzed. The diabetic rats 4 wk after alloxan treatment had significantly less phospholipid contents in the white layer from broncho-alveolar lavage fluid than the control. As to the phospholipid composition, the white layer of the diabetic rats contained significantly less phosphatidyl choline, and more sphingomyelin and lysophosphatidyl choline than the control. Diabetes mellitus may induce a disturbance in the synthesis of pulmonary surfactant.

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