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The lupus erythematosus cell phenomenon new aspects in molecular biology and immuno cytology


, : The lupus erythematosus cell phenomenon new aspects in molecular biology and immuno cytology. Archives of Dermatological Research 266(2): 197-204

The effects of antinuclear antibodies on nuclear material can be observed directly in free [human] leukocyte nuclei in the supravital preparation according to Engel. Antinuclear antibodies prevent lysis of free nuclei; they obstruct normal degeneration of nuclei. The nuclear blockade is recognizable in the dark-clodded, rigid nuclei which remain small. These blocked nuclei are the visible expression of a development of complexes between chromatin and antinuclear antibodies. The protective effect of antinuclear antibodies apparently consists of obstruction of the DNases and histone-proteases bound to chromatin. Effects of antinuclear antibodies are in agreement with the structure of the chromatin nucleosomes. The nuclear blockade caused a persistence of antigenic material, which can create an increase of antibody production. The antinuclear blockade is an effect which sustains illness in vivo.

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Anonymous, 1940: Transmission of Streptococcus agalactiae. One-tenth ml. of saline containing 185 colonies, 212 colonies, or 700 to 6, 000 cells of Streptococcus agalactiae was placed just above the sphincter in the teat canal of each of two quarters of the udders of six cows. Acute mastitis, leading to p...

Wilson, F. D.; George, B. W., 1981: Breeding potentials of noncultivated cottons gossypium hirsutum 5. productivity of cultivars race stocks and f 1 hybrids among them in long day and short day environments. Twelve primitive race stocks of cotton (G. hirsutum L.), 4 Upland cultivars and 24 race stock cultivar F1 hybrids were grown in 3 replicated tests in the summer at Phoenix, Arizona (USA) and in the winter at Isabela, Puerto Rico. Objectives of thi...

Ballabio, Andrea; Andria, Generoso, 1992: Deletions and translocations involving the distal short arm of the human X chromosome: Review and hypotheses. In this review we describe the various types of chromosomal abnormalities found in the distal short arm of the human X chromosome and the most common clinical features associated with each type, emphasizing the underlying molecular mechanisms. The...

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Annacker, Oliver; Asseman, Chrystelle; Read, Simon; Powrie, Fiona, 2003: Interleukin-10 in the regulation of T cell-induced colitis. Journal of Autoimmunity 20(4): 277-279, June

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