EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The lupus erythematosus cell phenomenon new aspects in molecular biology and immuno cytology


Archives of Dermatological Research 266(2): 197-204
The lupus erythematosus cell phenomenon new aspects in molecular biology and immuno cytology
The effects of antinuclear antibodies on nuclear material can be observed directly in free [human] leukocyte nuclei in the supravital preparation according to Engel. Antinuclear antibodies prevent lysis of free nuclei; they obstruct normal degeneration of nuclei. The nuclear blockade is recognizable in the dark-clodded, rigid nuclei which remain small. These blocked nuclei are the visible expression of a development of complexes between chromatin and antinuclear antibodies. The protective effect of antinuclear antibodies apparently consists of obstruction of the DNases and histone-proteases bound to chromatin. Effects of antinuclear antibodies are in agreement with the structure of the chromatin nucleosomes. The nuclear blockade caused a persistence of antigenic material, which can create an increase of antibody production. The antinuclear blockade is an effect which sustains illness in vivo.


Accession: 006712443



Related references

Lupus erythematosus in a patient with amyloidosis adrenal insufficiency and subsequent immuno blastic sarcoma demonstration of the lupus erythematosus phenomenon in the lung. Arthritis and Rheumatism 19(2): 249-255, 1976

The lupus erythematosus cell phenomenon: comparative analysis of antichromatin antibody specificity in lupus erythematosus cell-positive and -negative sera. Arthritis and Rheumatism 43(2): 420-428, 2000

Acute disseminated lupus erythematosus; clinical picture and nosographic considerations, collagen diseases, lupus erythematosus cells, lupus erythematosus phenomenon, Haserick's globulin. Prensa Medica Argentina 39(32): 1850-1856, 1952

Lupus erythematosus cell phenomenon in synovial and peritoneal fluids in systemic lupus erythematosus: smoking guns, crime scenes and a twist. International Journal of Rheumatic Diseases 18(1): 99-102, 2015

Malignant erythematodes (acute lupus erythematosus disseminatus); clinical picture and nosographic revaluation; collagen diseases; lupus erythematosus cells; lupus erythematosus phenomenon; Haserick's globulin. Revista Clinica Espanola 47(5): 309-314, 1952

The development of Hargrave's phenomenon (lupus erythematosus phenomenon) in vivo in lupus erythematosus acutus. Zeitschrift für Haut- und Geschlechtskrankheiten 14(6): 171-179, 1953

Case of discoid lupus erythematosus presenting a negative result for antinuclear antibody yet positive for LE cell phenomenon (pseudo-LE-cell phenomenon?). Naika. Internal Medicine 25(1): 177-180, 1970

Allergy in systemic lupus erythematosus immuno globulin e levels and reaginic phenomenon. Arthritis and Rheumatism 19(4): 669-674, 1976

The LE cell phenomenon. New aspects in molecular biology and immunocytology. Archives of Dermatological Research 266(2): 197-204, 1979

The inst immuno fluorescent band test for lupus erythematosus i morphologic variations of the band of localized immuno globulins at the dermal epidermal junction in lupus erythematosus human. Archives of Dermatology 99(4): 413-420, 1969