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The lupus inhibitor its heterogeneity


, : The lupus inhibitor its heterogeneity. Thrombosis & Haemostasis 46(4): 734-739

The plasmas of 6 patients with prolonged activated partial thromboplastin times were studied in detail. In 5 of the 6, the Russell's viper venom and prothrombin times were likewise prolonged. Five of the patients had documented systemic lupus erythematosus; one lacked the necessary criteria for this diagnosis. On quantitation, factor XI was decreased in all 6; factors X and XII were diminished in 5 of the 6. When tested for inhibitory activity, plasma from each of the patients prolonged the celite eluate inhibition test for factor XII and/or XI inhibition. In the formation of the factor Xa-factor V-phospholipid-Ca2+ complex (prothrombinase), factors X and Xa were inhibited to a greater degree than factor V or the phospholipid. Finally, each plasma was isofocused, the inhibitory fractions were identified and the clotting factor specificity of each inhibitory peak was determined. Fractions inhibitory against factors XI and XII isofocused with the IgG in each patient's plasma. The lupus inhibitor is apparently a heterogeneous collection of inhibitors directed against factors XII, XI and X rather than a homogeneous entity.

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