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The luteal breast hormonal and sonographic investigation of benign breast disease in patients with cyclic mastalgia

Fertility & Sterility 40(6): 779-784
The luteal breast hormonal and sonographic investigation of benign breast disease in patients with cyclic mastalgia
The pathophysiology, malignant potential and hormonal therapy for benign breast disease remain controversial. The anatomic and endocrinologic correlates of luteal phase mastodynia patients, compared with asymptomatic control subjects, are investigated. Objective sonographic evidence of fibrocystic disease (FCD) was found in 1/2 of both mastodynia and control groups. Endocrine abnormalities observed in the mastodynia group included significantly lower luteal phase progesterone and prolactin hyperresponsivenss to TRF. The presence or absence of anatomic FCD was not correlated with endocrine abnormalities. Cyclic mastalgia may be the end result of a dyshormonal milieu resembling the inadequate luteal phase, FCD may be hormonally independent and cyclic mastalgia and FCD are different, if often co-existent, factors in benign breast disease syndromes.

Accession: 006712454

PMID: 6653797

DOI: 10.1016/s0015-0282(16)47479-0

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