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The lympho proliferative response during human experimental gingivitis

Journal of Periodontal Research 14(4): 269-278
The lympho proliferative response during human experimental gingivitis
The lymphocyte blastogenic responses to antigen preparations of bacteria from dental microbial plaque and to other non-oral stimulants were longitudinally assayed in 8 adult subjects using the experimental gingivitis model. During the 28 days of the experimental period, these subjects abstained from all oral hygiene procedures which led to accumulation of increased amounts of microbial dental plaque and subsequent gingivitis. All subjects demonstrated a significant increase in the lymphoproliferative response to all doses of phytohemmaglutinin (PHA) during the experimental period. The subjects were divided into 2 groups based on rate of plaque accumulation. Slow plaque formers exhibited a gradual linear increase in blastogenic response to bacterial antigen [Ag] preparations throughout the experimental period. In the group characterized by rapid accumulation of plaque, a marked early increase in blastogenic responses to Ag of Actinomyces viscosus, A. naeslundii, Bacteroides melaninogenicus and Treponema denticola was observed. These same subjects demonstrated a reduction in lymphocyte response to the above Ag during the later phase of the experimental period, when gingivitis was most severe. This decrease, in light of the simultaneous increase in PHA response, suggests the existence of a homeostatic mechanism to control the immune response during episodes of increased Ag load.

Accession: 006712542

PMID: 161574

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