EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The lyt phenotype of cells involved in the cyto toxic response to syngeneic tumor and tumor specific suppressor cells






Cellular Immunology 56(2): 392-399

The lyt phenotype of cells involved in the cyto toxic response to syngeneic tumor and tumor specific suppressor cells

Suppressor cells, which specifically suppress the in vitro response of syngeneic spleen cells to the DBA/2 mastocytoma, P815, were identified in the spleens of DBA/2 mice injected i.p. with membrane extracts of the P815 tumor. The Lyt phenotypes of various effector cells were determined. DBA/2 allogeneic killer cells were identified as Lyt-12+, whereas the syngeneic effector cells were predominantly Lyt-2+. The suppressor cell population lost its ability to suppress the in vitro cytotoxic anti-P815 response after treatment with anti-Lyt-1 serum plus complement but not after treatment with anti-Lyt-2 serum, indicating that an Lyt-1+ cell is essential in this suppression.


Accession: 006712641

PMID: 6451300



Related references

Separation of lymphoid cells with a suppressor effect on the activity of cyto toxic cells in vitro during the growth of a syngeneic mouse tumor. International Journal of Cancer 21(3): 329-333, 1978

Ly phenotype of cyto toxic thymus derived cells for syngeneic tumor. Journal of Experimental Medicine 144(4): 1116-1120, 1976

Studies on chemically induced tumors in rats 1. heterogeneity of tumor cells and establishment of syngeneic tumor specific cyto toxic t cell clones. Experientia (Basel) 39(1): 39-47, 1983

Effect of bcg cell wall skeleton on the induction of the cyto toxic and suppressor t cells against syngeneic tumor in the mouse. International Journal of Cancer 27(6): 829-836, 1981

Suppressive effect of x irradiated tumor cell pre sensitization on the induction of syngeneic tumor immunity 2. opposite effects of intra venous administration of tri nitro phenyl conjugated tumor cells on the development of anti tumor and anti self cyto toxic effector cells. Cellular Immunology 59(1): 181-186, 1981

Regulation of immune responses against the syngeneic adj pc 5 plasmacytoma in balb c mice iv. tumor specific t suppressor cells induced at early stages of tumorigenesis act on the induction phase of the tumor specific cytotoxic t cell response. Immunobiology 171(4-5): 357-365, 1986

Requirement of histo compatible macrophages for the induction of a secondary cyto toxic response to syngeneic tumor cells in vitro. Journal of Immunology 123(1): 43-49, 1979

Cyto toxic activity of lymphoid cells from mice immunized with semi allogenic hybrid cells requirement of in vitro lymphoid cells culture for expression of cyto toxicity against a syngeneic chemically induced tumor. Cellular Immunology 74(2): 383-393, 1982

Suppression of the in vitro secondary response to syngeneic tumor and in vivo tumor therapy with immune cells by culture induced suppressor cells. Journal of Immunology 123(2): 515-522, 1979

Differential recognition by cyto toxic and suppressor thymus derived cells in the immune response against syngeneic tumors. Gann Monograph on Cancer Research, No 28 Adult T Cell Leukemia And Related Diseases Viii+243p Japan Scientific Societies Press: Tokyo, Japan; Plenum Press: New York, N Y , Usa; London, England Illus Isbn 4-7622-6349-4; Isbn 0-3064-1335-3 1982 Viii+243p P193-200, 1979