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The lyt phenotype of cells involved in the cyto toxic response to syngeneic tumor and tumor specific suppressor cells

Cellular Immunology 56(2): 392-399

The lyt phenotype of cells involved in the cyto toxic response to syngeneic tumor and tumor specific suppressor cells

Suppressor cells, which specifically suppress the in vitro response of syngeneic spleen cells to the DBA/2 mastocytoma, P815, were identified in the spleens of DBA/2 mice injected i.p. with membrane extracts of the P815 tumor. The Lyt phenotypes of various effector cells were determined. DBA/2 allogeneic killer cells were identified as Lyt-12+, whereas the syngeneic effector cells were predominantly Lyt-2+. The suppressor cell population lost its ability to suppress the in vitro cytotoxic anti-P815 response after treatment with anti-Lyt-1 serum plus complement but not after treatment with anti-Lyt-2 serum, indicating that an Lyt-1+ cell is essential in this suppression.

Accession: 006712641

PMID: 6451300

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