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The macrocellular (large cell) carcinomas of the lung. A histopathological analysis of 880 diagnosed cases

, : The macrocellular (large cell) carcinomas of the lung. A histopathological analysis of 880 diagnosed cases. Morphologie et Embryologie 32(1): 23-32

Taking into account the negative characterization of macrocellular carcinomas of the WHO's Typing of Lung Tumors (1982).sbd.neither epidermoid, nor adenocarcinoma.sbd.and formed in order to ascertain the own characters of the group. There were studied 432 lung resections (mostly lobectomies, but also pulmonectomies and atypical segmentectomies), 429 biopsies (mostly bronchial, but also lymphonodal and pleural) and 19 autopsies of undiagnosed cases. 3-8 fragments from each specimen, except for bronchial biopsies, were studied: histochemical methods were also used. The examination allowed the distinction of 483 cases with a prominently monomorphous proliferation and 397 cases with a pleomorphous structure. The latter was due to both the cytological structure and arrangement. The peripheral parts of such cases presented sometimes rare epidermoid differentiations, and the penetration within more hard structures (fibrous areas, scars) was accompanied by the local appearance of pseudotubular and pseudoglandular arrangements of neoplastic cells without any sign of secretion. All these local differentiations were statistically unsignificant in the whole tumor. The histological study revealed a poorly differention of proliferative structures, the rare giant cells, the relatively rare sign of differentiation appearing to be locally, promotionally-conditioned, and not determined by the own characters of proliferating malignant cells. This analysis enforced the consideration of macrocellular (large cell) carcinomas of the lung as forming an entity, a basic proliferating-differentiating type, the lowest differentiated of all lung carcinoma types.

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