EurekaMag.com logo
+ Translate

The macrophage in Hodgkin's disease


, : The macrophage in Hodgkin's disease. Journal of Pathology 133(2): 145-159

Methods used to separate macrophages from human lympho-medullary tissue samples have been applied to involved and uninvolved spleens and lymph nodes from 44 patients with Hodgkin's disease. The tumour samples yielded a population of ultrastructurally atypical cells with the anatomical and functional attributes of macrophages. The findings suggest that the macrophage was the neoplastic element in the cases of Hodgkin's disease studied. A feature of samples of uninvolved tissue from Hodgkin's disease patients was that there were fewer macrophages identifiable in the samples than in the normal control tissues. These findings suggest that they may be a deficiency of normal macrophages as well as macrophage neoplasia in this disease. Both abnormalities would contribute to the defective cell-mediated immunity which is a characteristic of Hodgkin's disease.

Accession: 006712770

PMID: 7205444

DOI: 10.1002/path.1711330206

Download PDF Full Text: The macrophage in Hodgkin's disease


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Ree, H.J.; Kadin, M.E., 1985: Macrophage-histiocytes in Hodgkin's disease. The relation of peanut-agglutinin-binding macrophage-histiocytes to clinicopathologic presentation and course of disease. The authors studied the occurrence of peanut agglutinin (PNA)-binding cells in paraffin-embedded specimens of 145 patients with Hodgkin's disease (HD). The staining reaction of lymphocytes was consistently negative. A positive staining reacti...

Claret, E.; Praloran, V.; Zheng, X.; Bonnefoix, T.; Sotto, M.F.; Renversez, J.C.; Piccinni, M.P.; Berrada, L.; Sotto, J.J., 1992: Accumulation of T-cell clones producing high levels of both granulocyte-macrophage and macrophage colony-stimulating factors (CSF-1) in lymph nodes involved by Hodgkin's disease. We have previously shown that total T cells derived from lymph nodes (LN) involved by Hodgkin's disease (HD) secrete higher levels of colony-stimulating activity than total T cells present within benign hyperplastic (BH) LN and B-non-Hodgkin&...

Estévez, M.E.; Ballart, I.J.; Diez, R.A.; Sen, L., 1989: The monocyte-macrophage system in Hodgkin's disease. Hodgkin's disease (HD) is considered as a tumor of the lymph nodes histologically characterized by a variety of cell types, resembling a nonspecific inflammatory reaction. The Reed-Sternberg cells present in the granuloma are considered neopl...

Kohl, S.; Pickering, L.K.; Sullivan, M.P.; Walters, D.L., 1980: Impaired monocyte-macrophage cytotoxicity in patients with Hodgkin's disease. Clinical Immunology and Immunopathology 15(4): 577-585

Ree, H.J., 1987: Stromal macrophage-histiocytes in Hodgkin's disease. Their relation to fever. Morphologic variations of Concanavalin A-binding histiocytes were studied in biopsy specimens of 140 untreated patients with Hodgkin's disease (72 asymptomatic, and 68 with constitutional symptoms). Fever was the most common symptom, present...

Sokol, R.J.; Hudson, G.; James, N.T.; Wales, J., 1988: Abnormal macrophage development in Hodgkin's disease: a morphometric study. The development of macrophages from blood monocytes from 22 patients with untreated Hodgkin's disease and 20 normal subjects has been studied at intervals over a 6-day period of suspension culture in the presence of autologous serum and lymph...

Sokol, R.J., 1988: Changes in nucleolar morphology during macrophage development in Hodgkin's disease: a morphometric study. In view of the importance of nucleoli in the regulation of cell growth and protein synthesis, and in consideration of the fact that morphological changes have been found in mononuclear phagocytes in patients with malignant lymphoma, a study was ma...

Sokol, R.J.; Hudson, G.; Wales, J.M.; Goldstein, D.J.; James, N.T., 1993: Disordered macrophage development in Hodgkin's disease shown by quantitative cytochemistry. In order to investigate the disordered maturation of mononuclear phagocytes previously found in Hodgkin's disease, integrating microdensitometry was used to quantitate changes in seven cytochemical constituents (NADH dehydrogenase, succinate...

von Wasielewski, R.; Werner, M.; Fischer, R.; Hansmann, M.L.; Hübner, K.; Hasenclever, D.; Franklin, J.; Sextro, M.; Diehl, V.; Georgii, A., 1997: Lymphocyte-predominant Hodgkin's disease. An immunohistochemical analysis of 208 reviewed Hodgkin's disease cases from the German Hodgkin Study Group. There is wide consensus that lymphocyte predominance Hodgkin's disease (LPHD) represents a distinct clinicopathological entity of B-cell origin. However, inconsistent results of immunophenotyping studies and low confirmation rates among multi...

Steigbigel, R.T.; Lambert, L.H.; Remington, J.S., 1976: Polymorphonuclear leukocyte, monocyte, and macrophage bactericidal function in patients with Hodgkin's disease. To determine if the susceptibility of patients with lymphoma, particularly Hodgkin's lymphoma, is related to an abnormality in leukocyte function, the serum, neutrophils and monocytes from 29 patients with all stages of untreated Hodgkin&apos...