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The macrophage membrane potential test an electro physiological modification of the field caspary test in melanoma patients


Acta Biologica et Medica Germanica 34(11-12): 1911-1914
The macrophage membrane potential test an electro physiological modification of the field caspary test in melanoma patients
In modification of the Field and Caspary cytopherometric test, the influence of the cell-free supernatant (lymphokine) from the lymphocyte antigenic reaction on the transmembrane potential of macrophages obtained from guinea pigs (peritoneal exudate cells [PEC]) was studied. Macrophage membrane potential (MMP) was determined by the glass microelectrode technique. In agreement with histological and clinical findings in malignant melanoma and malignant Dubreuilh's disease, a depolarization of the macrophage membrane of up to 40% was observed. A depolarization up to 60% was obtained in patients having undergone BCG vaccination, if the antigen used was PPD [purified protein derivative]. In control persons and in non-malignant pigmentary tumors (such as foreign body granuloma) no variation of MMP was found. Cell mediated immunity is probably closely correlated with membrane permeabilities, ion gradients and cell metabolism.


Accession: 006712774



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