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The macrophage membrane potential test an electro physiological modification of the field caspary test in melanoma patients

, : The macrophage membrane potential test an electro physiological modification of the field caspary test in melanoma patients. Acta Biologica et Medica Germanica 34(11-12): 1911-1914

In modification of the Field and Caspary cytopherometric test, the influence of the cell-free supernatant (lymphokine) from the lymphocyte antigenic reaction on the transmembrane potential of macrophages obtained from guinea pigs (peritoneal exudate cells [PEC]) was studied. Macrophage membrane potential (MMP) was determined by the glass microelectrode technique. In agreement with histological and clinical findings in malignant melanoma and malignant Dubreuilh's disease, a depolarization of the macrophage membrane of up to 40% was observed. A depolarization up to 60% was obtained in patients having undergone BCG vaccination, if the antigen used was PPD [purified protein derivative]. In control persons and in non-malignant pigmentary tumors (such as foreign body granuloma) no variation of MMP was found. Cell mediated immunity is probably closely correlated with membrane permeabilities, ion gradients and cell metabolism.

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