+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

The magnitude and duration of respiratory depression produced by fentanyl and fentanyl plus droperidol in man

Journal of Pharmacology and Experimental Therapeutics 199(2): 464-468
The magnitude and duration of respiratory depression produced by fentanyl and fentanyl plus droperidol in man
In 10 healthy male volunteers breathing 100% oxygen, we determined the effect of four intravenous dose levels of fentanyl (0.0015, 0.003, 0.006 and 0.009 mg/kg) and two of fentanyl plus droperidol (i.e., Innovar, 0.003 and 0.006 mg/kg of fentanyl with 2.5 mg of droperidol for each 0.05 mg of fentanyl) on PECO2 and the slope of the ventilatory response to imposed increases in PECO2. All doses of fentanyl and fentanyl plus droperidol depressed the slope and shifted the curve to the right. Depression was dose related and was maximum 5 minutes after administration. The slope returned to control by 2 hours postinjection even at the highest narcotic dose. However, the rightward shift of the CO2 response curve require 4 hours to return to control. Droperidol added to fentanyl did not increase or prolong the respiratory depression seen with fentanyl alone at equivalent dose levels. Nausea and emesis occurred more frequently with fentanyl alone and orthostatic hypotension occurred more frequently with droperidol plus fentanyl. Dysphoria was a prominent consequence of fentanyl plus droperidol administration.

Accession: 006712879

PMID: 978496

DOI: 10.1097/00132586-197708000-00005

Related references

The magnitude and duration of respiratory depression due to fentanyl and meperidine in man. Journal of Pharmacology and Experimental Therapeutics 158(3): 416-420, 1967

Differences in magnitude and duration of opioid-induced respiratory depression and analgesia with fentanyl and sufentanil. Anesthesia and Analgesia 70(1): 8-15, 1990

Total intravenous anesthesia (TIVA): clinical comparison of 2 pharmacologic combinations: flunitrazepam-droperidol-fentanyl and propofol-droperidol-fentanyl. Minerva Anestesiologica 57(9): 630-631, 1991

Circulatory and respiratory response to tilt with pentazocine , droperidol droperidol-fentanyl , and methotrimeprazine in normal healthy male subjects. 1965

A comparison between the effects of fentanyl, droperidol with fentanyl, and halothane anaesthesia on intra-ocular pressure in adults. Anaesthesia 42(3): 266-269, 1987

Comparative analgesic kinetics of fentanyl and droperidol fentanyl association. Anesthesie Analgesie Reanimation 38(5-6): 235-241, 1981

Comparisons of effects of morphine, meperidine, fentanyl, and fentanyl-droperidol. Clinical Pharmacology and Therapeutics 11(4): 488-495, 1970

Hemodynamic and ventilatory responses to fentanyl, fentanyl-droperidol, and nitrous oxide in patients with acquired valvular heart disease. Anesthesiology 42(3): 319-324, 1975

Midazolam for intramuscular premedication: dose-effect relationships compared to diazepam, fentanyl and fentanyl-droperidol in a placebo controlled study. Acta Anaesthesiologica Belgica 37(2): 127-136, 1986

Neuroleptanalgesia Produced By Fentanyl And Droperidol. Journal of the American Veterinary Medical Association 145: 897-902, 1964