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The maintenance of cytochrome p 450 in liver cell culture recent studies on cytochrome p 450 mediated mechanisms of toxicity


, : The maintenance of cytochrome p 450 in liver cell culture recent studies on cytochrome p 450 mediated mechanisms of toxicity. Toxicology 25(1): 41-47

Rat hepatocytes were cultured under conditions that resulted in low and high cytochrome P-450 concentrations and then used as a screening test to determine the involvement of cytochrome P-450 in toxicity. Apparently, a limitation to the use of cultured hepatocytes in toxicity tests is the lack of extrahepatic release mechanisms of toxic compounds.

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Rand, A. Stanley, 1967: Ecology and social organization in the iguanid lizard Anolis lineatopus. Intensive observations were made on marked individuals during a 10-month field study near Kingston, Jamaica. A. lineatopus is an abundant anole, arboreal and diurnal in habits; adult males are larger than females. A generalized insector, it shows...

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Bishop, James F.; Dewar, Joanna; Toner, Guy C.; Smith, Jennifer; Tattersall, Martin H.N.; Olver, Ian N.; Ackland, Stephen; Kennedy, Ian; Goldstein, David; Gurney, Howard; Walpole, Euan; Levi, John; Stephenson, Jennifer; Canetta, Renzo, 1999: Initial paclitaxel improves outcome compared with CMFP combination chemotherapy as front-line therapy in untreated metastatic breast cancer. Purpose: To determine the place of single-agent paclitaxel compared with nonanthracycline combination chemotherapy as front-line therapy in metastatic breast cancer. Patients and Methods: Patients with previously untreated metastatic breast cancer...

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Velez Fortuno, Jesus, 1952: Corn-breeding work in Puerto Rico. Mayorbela, at present the standard corn var. in Puerto Rico, was produced at the Isabela Sub-Station from a local var. crossed with the best S5 lines at the Mayaguez Station, and subjected to mass selection. The inbred lines that have been develop...

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