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The melanotropic peptides vi. the benzodiazepine agonist clonazepam potentiates the effects of gamma aminobutyric acid on alpha msh release from neurointermediate lobes in vitro



The melanotropic peptides vi. the benzodiazepine agonist clonazepam potentiates the effects of gamma aminobutyric acid on alpha msh release from neurointermediate lobes in vitro



Life Sciences 40(19): 1881-1888



The action of the central-type benzodiazepine-receptor agonist clonazepam on .alpha.-MSH release has been studied in vitro using perifused frog neutrointermediate lobes. High concentrations of clonazepam (3.16 .times. 10-5 and 10-4 M) caused an inhibition of .alpha.-MSH release and this effect was reversed by the central-type benzodiazepine-receptor antagonist Ro 15-1788. High doses of GABA (10-5 and 10-4 M) induced a biphasic effect on pars intermedia cells: a brief stimulation followed by a sustained inhibition of .alpha.-MSH secretion. Administration of clonazepam (10-5 M) in the present of various concentrations of GABA (10-6 to 10-4 M) led to a potentiation of both stimulatory and inhibitory phases of .alpha.-MSH secretion induced by GABA. Ro 15-1788 completely abolished the potentiating effect of clonazepam. Thus our results indicate that endogenous benzodiazepine receptors may modulate the effects of GABA on .alpha.-MSH secretion.

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