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The metabolic effects of surgical trauma on growing rats


Journal of Nutrition 108(11): 1830-1841
The metabolic effects of surgical trauma on growing rats
The metabolic effects of surgical trauma on growing female rats were investigated. In the 1st experiment 3 groups of rats were included: a control group (no treatment), an operated group (uteri removed) and a sham-operated (incision only). In a 2nd experiment including the operated group and sham-operated groups, another group was added; a sham-operated food restricted group (SOFR). The rats in the SOFR group were sham-operated but their food was restricted to the amount of food consumed by the operated group. In the 1st experiment, rats lost body weight following the surgery, but were able to regain the lost weight. Normal weight levels were achieved by 6 days post operation by increasing the efficiency of food utilization. In the 2nd experiment, the SOFR were unable to maintain normal body weight gain. Nitrogen balance was significantly greater in operated rats compared to unoperated and sham-operated rats on the 1st day following surgery in the 1st experiment. In the 2nd experiment N balance was similar in operated and SOFR rats, but less than in the sham-operated controls. Plasma RNase levels were significantly elevated in the operated rats on the 1st day following surgery (PO1). Plasma glucose levels on any post operative day were not significantly different from the control groups, but were higher on PO1 than on PO2, PO3 and PO4. The plasma ketone levels were not significantly affected by the surgical trauma. The plasma total amino acid level was lowest on PO3 and was higher than the control on PO6. The increase in amino acid levels in the operated groups correlated with the rapid weight gain from PO3 to PO6. Following surgery total acidic amino acids and ketogenic amino acids were unaltered. The glucogenic, sulfur, and non-essential amino acids contributed more to the increase in the PO6 group of rats than did the basic, essential and acidic amino acids. The mechanism of altered plasma amino acids probably relates to their use as precursors and substrates for gluconeogenesis and helps to determine amino acid requrements of traumatized patients.


Accession: 006717097

PMID: 712427



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