+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

The metabolic effects of surgical trauma on growing rats

The metabolic effects of surgical trauma on growing rats

Journal of Nutrition 108(11): 1830-1841

The metabolic effects of surgical trauma on growing female rats were investigated. In the 1st experiment 3 groups of rats were included: a control group (no treatment), an operated group (uteri removed) and a sham-operated (incision only). In a 2nd experiment including the operated group and sham-operated groups, another group was added; a sham-operated food restricted group (SOFR). The rats in the SOFR group were sham-operated but their food was restricted to the amount of food consumed by the operated group. In the 1st experiment, rats lost body weight following the surgery, but were able to regain the lost weight. Normal weight levels were achieved by 6 days post operation by increasing the efficiency of food utilization. In the 2nd experiment, the SOFR were unable to maintain normal body weight gain. Nitrogen balance was significantly greater in operated rats compared to unoperated and sham-operated rats on the 1st day following surgery in the 1st experiment. In the 2nd experiment N balance was similar in operated and SOFR rats, but less than in the sham-operated controls. Plasma RNase levels were significantly elevated in the operated rats on the 1st day following surgery (PO1). Plasma glucose levels on any post operative day were not significantly different from the control groups, but were higher on PO1 than on PO2, PO3 and PO4. The plasma ketone levels were not significantly affected by the surgical trauma. The plasma total amino acid level was lowest on PO3 and was higher than the control on PO6. The increase in amino acid levels in the operated groups correlated with the rapid weight gain from PO3 to PO6. Following surgery total acidic amino acids and ketogenic amino acids were unaltered. The glucogenic, sulfur, and non-essential amino acids contributed more to the increase in the PO6 group of rats than did the basic, essential and acidic amino acids. The mechanism of altered plasma amino acids probably relates to their use as precursors and substrates for gluconeogenesis and helps to determine amino acid requrements of traumatized patients.

(PDF emailed within 1 workday: $29.90)

Accession: 006717097

Download citation: RISBibTeXText

PMID: 712427

Related references

Effects on the normalization of amino acids in metabolic support for trauma surgical patients. Zhonghua Wai Ke Za Zhi 30(11): 659-62, 699, 1992

Metabolic and endocrine alterations provoked by surgical trauma; effects on cicatrization and restoration of tissues. Anais Paulistas de Medicina E Cirurgia 60(2): 120-121, 1950

Metabolic effects and cardiorespiratory interactions during total parenteral nutrition in surgical trauma and sepsis. Clinica Dietologica 13(6): 601-604, 1986

Effects of reserpine on metabolic changes of medullectomized rats subjected to trauma. Physioloslov.. : 354, 1970

Studies in surgical endocrinology. I. The urinary excretion of 17-hydroxycorticoids, and associated metabolic changes, in cases of soft tissue trauma of varying severity and in bone trauma. Annals of Surgery 141(2): 145-174, 1955

Metabolic effects of histidine-deficient diets fed to growing rats by gastric tube. Journal of Nutrition 114(11): 2138-2146, 1984

The effects of x irradiation and surgical trauma on the cell kinetics of the subependyma plate of rats. Radiation Research 59(1): 278-279, 1974

Metabolic effects of glucose compared with invertose and a mixture of fructose, glucose and xylitol before and after moderate surgical trauma. Clinical Nutrition 3(2): 111-117, 1984

Effects of dietary consumption of cranberry powder on metabolic parameters in growing rats fed high fructose diets. Food & Function 1(1): 116-123, 2012

Effects of acute and chronic level of protein supply on metabolic leucine utilization in growing and mature rats. British Journal of Nutrition 70(1): 117-125, 1993

Metabolic effects of zinc deficiency on the somatotropic axis in non-growing rats as a new animal model to adult individuals. Journal of Dairy Science 85(Supplement 1): 351, 2002

Effects of experimental surgical trauma on the acid base balance in albino rats treated with various anesthetics. Bollettino Societa Italiana Biologia Sperimentale 52(15): 1176-1182, 1976

Metabolic changes in trauma-resistant rats following trauma. Canadian Journal of Biochemistry and Physiology 36(4): 457-464, 1958

Sodium ascorbate (ASC) and ascorbic acid phosphate (ASC-P) differently modulate glucocorticoid-dependent metabolic effects in growing rats. Archiv fur Tierzucht 49(Special Issue): 41-51, 2006

Effects of surgical stress on renal neoglucogenesis during metabolic acidosis in rats. Journal de Physiologie 62 Suppl 3: 381-381, 1970