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The metabolic serum clearance of gonadotropin releasing hormone relationship to age sex and male puberty



The metabolic serum clearance of gonadotropin releasing hormone relationship to age sex and male puberty



Hormone & Metabolic Research 13(5): 277-282



The MCR [metabolic clearance rate] of constantly infused synthetic GnRH [gonadotropin releasing hormone] (1.53 .mu.g/min) was studied in relation to age, sex and male sexual maturation. GnRH was determined by a radioimmunoassay [RIA] using a specific GnRH antiserum and 125I-GnRH, prepared by the chloramine T technique and purified on Sephadex G 25. Serum LH [luteinizing hormone] and FSH were measured by RIA. The results (mean values .+-. SEM [standard error of the mean]) of MCR expressed as ml/min/1.86 m2 showed a statistically significant difference: infants (6-13 yr) 1170 .+-. 79, sexually mature males (22-29 yr) 639 .+-. 28, elderly men (64-79 yr) 520 .+-. 38, sexually mature females (20-24 yr) follicular phases: 1354 .+-. 90, luteal phases: 1736 .+-. 242, postmenopausal women (53-74 yr) 598 .+-. 45. A linear negative correlation was found between serum LH and MCR of GnRH in both sexes. During male puberty the MCRGnRH decreased simultaneously to the stages of pubic hair development. The MCR of GnRH is a function of age, sex and sexual maturation; its negative linear correlation with LH in both sexes indicates that the MCR presumably reflects endogenous GnRH levels. The MCRGnRH seems to be subject to endocrine regulation.

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