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The metabolism and active excretion of hypo xanthine by the renal tubules in the chicken



The metabolism and active excretion of hypo xanthine by the renal tubules in the chicken



Journal of Pharmacology and Experimental Therapeutics 207(2): 574-583



Infusion of [14C]hypoxanthine into 1 renal portal circulation of the chicken resulted in an excess of [14C]uric acid excreted into the urine from the infused side kidney. No [14C]hypoxanthine appeared in the urine from either kidney. When the renal metabolism of [14C]hypoxanthine was inhibited by xanthine dehydrogenase inhibitors, almost no excess 14C-label appeared in the urine of the infused side, suggesting that formation of nephrogenic urate plays an important role in the tubular excretion of hypoxanthine. A comparison of the effects of inhibitors on the renal excretion of preformed urate and nephrogenic urate suggests the existence of a p-aminohippurate-independent transport step for purines at the luminal membrane of the renal tubular cell. Studies with transport inhibitors suggest that the active transport step is anionic in character.

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Accession: 006717238

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